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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A. Chen HT, et al. Among authors: nussenzweig a. Science. 2000 Dec 8;290(5498):1962-5. doi: 10.1126/science.290.5498.1962. Science. 2000. PMID: 11110662 Free PMC article.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsuk M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A. Petersen S, et al. Among authors: nussenzweig a, nussenzweig mc. Nature. 2001 Dec 6;414(6864):660-665. doi: 10.1038/414660a. Nature. 2001. PMID: 11740565 Free PMC article.
Genomic instability in mice lacking histone H2AX.
Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A. Celeste A, et al. Among authors: nussenzweig a, nussenzweig mc. Science. 2002 May 3;296(5569):922-7. doi: 10.1126/science.1069398. Epub 2002 Apr 4. Science. 2002. PMID: 11934988 Free PMC article.
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. Fernandez-Capetillo O, et al. Among authors: nussenzweig a. Nat Cell Biol. 2002 Dec;4(12):993-7. doi: 10.1038/ncb884. Nat Cell Biol. 2002. PMID: 12447390
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y. Furuta T, et al. Among authors: nussenzweig a. J Biol Chem. 2003 May 30;278(22):20303-12. doi: 10.1074/jbc.M300198200. Epub 2003 Mar 25. J Biol Chem. 2003. PMID: 12660252 Free article.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A. Celeste A, et al. Among authors: nussenzweig a. Cell. 2003 Aug 8;114(3):371-383. doi: 10.1016/s0092-8674(03)00567-1. Cell. 2003. PMID: 12914701 Free PMC article.
229 results