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Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents.
ACS Med Chem Lett. 2017 Oct 9;8(11):1165-1170. doi: 10.1021/acsmedchemlett.7b00287. eCollection 2017 Nov 9.
ACS Med Chem Lett. 2017.
PMID: 29152049
Free PMC article.
Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties.
Yang T, Moreira W, Nyantakyi SA, Chen H, Aziz DB, Go ML, Dick T.
Yang T, et al. Among authors: nyantakyi sa.
J Med Chem. 2017 Apr 13;60(7):2745-2763. doi: 10.1021/acs.jmedchem.6b01530. Epub 2017 Mar 28.
J Med Chem. 2017.
PMID: 28290692
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Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity.
Nyantakyi SA, Li M, Gopal P, Zimmerman M, Dartois V, Gengenbacher M, Dick T, Go ML.
Nyantakyi SA, et al.
J Med Chem. 2018 Jul 12;61(13):5733-5750. doi: 10.1021/acs.jmedchem.8b00777. Epub 2018 Jun 25.
J Med Chem. 2018.
PMID: 29894180
Free PMC article.
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Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility.
Tan YJ, Li M, Gunawan GA, Nyantakyi SA, Dick T, Go ML, Lam Y.
Tan YJ, et al. Among authors: nyantakyi sa.
ACS Med Chem Lett. 2020 Nov 16;12(5):704-712. doi: 10.1021/acsmedchemlett.0c00588. eCollection 2021 May 13.
ACS Med Chem Lett. 2020.
PMID: 34055215
Free PMC article.
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The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs.
Chen H, Nyantakyi SA, Li M, Gopal P, Aziz DB, Yang T, Moreira W, Gengenbacher M, Dick T, Go ML.
Chen H, et al. Among authors: nyantakyi sa.
Front Microbiol. 2018 Jul 19;9:1627. doi: 10.3389/fmicb.2018.01627. eCollection 2018.
Front Microbiol. 2018.
PMID: 30072978
Free PMC article.
Review.
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Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition.
Li M, Phua ZY, Xi Y, Xu Z, Nyantakyi SA, Li W, Jackson M, Wong MW, Lam Y, Chng SS, Go ML, Dick T.
Li M, et al. Among authors: nyantakyi sa.
ACS Infect Dis. 2020 Jul 10;6(7):1882-1893. doi: 10.1021/acsinfecdis.0c00121. Epub 2020 May 29.
ACS Infect Dis. 2020.
PMID: 32413266
Free PMC article.
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Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.
Li M, Nyantakyi SA, Go ML, Dick T.
Li M, et al. Among authors: nyantakyi sa.
Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01100-20. doi: 10.1128/AAC.01100-20. Print 2020 Nov 17.
Antimicrob Agents Chemother. 2020.
PMID: 32958714
Free PMC article.
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