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Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p.
Pala M, Meral I, Pala Acikgoz N, Mengi M, Erdim Gokce MB, Unsal R, Polat Y, Akbas F, Gorucu Yilmaz S. Pala M, et al. Behav Pharmacol. 2024 Apr 25. doi: 10.1097/FBP.0000000000000776. Online ahead of print. Behav Pharmacol. 2024. PMID: 38660812
Male adult Wistar albino rats (200-230 g, n = 36) were randomly assigned to six groups: Sham, thymoquinone (10 mg/kg, p.o.), 6-OHDA, 6-OHDA + thymoquinone (10 mg/kg), 6-OHDA + thymoquinone (20 mg/kg), and 6-OHDA + thymoquinone (50 mg/kg). ...Striatum samples were stained w …
Male adult Wistar albino rats (200-230 g, n = 36) were randomly assigned to six groups: Sham, thymoquinone (10 mg/kg, p.o.), 6-OHDA, …
Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.
Tang SY, Lordan R, Meng H, Auerbach BJ, Hennessy EJ, Sengupta A, Das US, Joshi R, Marcos-Contreras OA, McConnell R, Grant GR, Ricciotti E, Muzykantov VR, Grosser T, Weiljie AM, FitzGerald GA. Tang SY, et al. Arterioscler Thromb Vasc Biol. 2024 Apr 25. doi: 10.1161/ATVBAHA.123.320295. Online ahead of print. Arterioscler Thromb Vasc Biol. 2024. PMID: 38660804
RGD targeted magnetic ferrite nanoparticles enhance antitumor immunotherapeutic efficacy by activating STING signaling pathway.
Shi G, Liu X, Du Y, Tian J. Shi G, et al. iScience. 2024 Feb 1;27(5):109062. doi: 10.1016/j.isci.2024.109062. eCollection 2024 May 17. iScience. 2024. PMID: 38660408 Free PMC article.
Moreover, RGD-MnFe(2)O(4) can activate STING pathway with low toxicity to enhance the PD-L1 expression. Furthermore, combining RGD-MnFe(2)O(4) and anti-PD-L1 antibody (aPD-L1) can treat several types of immunogenic tumors through promoting the accumulation of tumor- …
Moreover, RGD-MnFe(2)O(4) can activate STING pathway with low toxicity to enhance the PD-L1 expression. Furthermore, combining RGD-Mn …
Utah Latina/o/x suicide decedents less likely to die by firearm, even in rural areas: examining population-wide data from the Utah Office of the Medical Examiner.
Tharp D, Goldstein EV, Medina RM, Brewer SC, Bakian AV, Coon H. Tharp D, et al. Front Public Health. 2024 Apr 10;12:1358043. doi: 10.3389/fpubh.2024.1358043. eCollection 2024. Front Public Health. 2024. PMID: 38660351 Free PMC article.
INTRODUCTION: Suicide death remains a significantly rarer event among Latina/o/x populations compared to non-Latina/o/x populations. However, the reasons why Latina/o/x communities experience relatively lower suicide rates are not fully understood. Critical g …
INTRODUCTION: Suicide death remains a significantly rarer event among Latina/o/x populations compared to non-Latina/o/x popula …
Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis.
van Egmond EEA, van der Hiele K, de Rooij MJ, van Gorp DAM, Jongen PJ, van der Klink JJL, Reneman MF, Beenakker EAC, van Eijk JJJ, Frequin STFM, de Gans K, Hoitsma E, Gerlach OHH, Mostert JP, Verhagen WIM, Visser LH, Middelkoop HAM. van Egmond EEA, et al. IBRO Neurosci Rep. 2024 Apr 15;16:518-526. doi: 10.1016/j.ibneur.2024.04.002. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38660124 Free PMC article.
Pro-inflammatory interactions of streptolysin O toxin with human neutrophils in vitro.
Joseph D, Theron AJ, Feldman C, Anderson R, Tintinger GR. Joseph D, et al. J Immunotoxicol. 2024 Dec;21(1):2345152. doi: 10.1080/1547691X.2024.2345152. Epub 2024 Apr 25. J Immunotoxicol. 2024. PMID: 38659406
The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, Streptococcus pyogenes, has focused attention on this microbial pathogen, which produces an array of virulence factors, such as the pore-forming toxin, streptolysin O (SOT …
The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, Streptococcus pyogenes, has focused at …
The Molecular Characteristics and Therapeutic Implications of O-Glycan Synthesis in Pancreatic Cancer by Integrating Transcriptome and Single-Cell Data.
Huang B, Zhang B, Liu J, Wang T, Zhang Y, Zhang B, Yuan Q, Xia S, Shang D. Huang B, et al. Curr Med Chem. 2024 Apr 24. doi: 10.2174/0109298673293445240409060446. Online ahead of print. Curr Med Chem. 2024. PMID: 38659264
PCs in OGRGcluster C2 had a more advanced clinical stage and pathological grade, worse prognosis, and more active O-glycan biosynthesis function. Immune analysis indicated that naive B cell, CD8+ T cell, memory-activated CD4+ T cell, and monocytes displayed r …
PCs in OGRGcluster C2 had a more advanced clinical stage and pathological grade, worse prognosis, and more active O-glycan biosynthes …
Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer.
Han R, Guo H, Shi J, Zhao S, Jia Y, Liu X, Liu Y, Cheng L, Zhao C, Li X, Zhou C. Han R, et al. BMC Med. 2024 Apr 24;22(1):174. doi: 10.1186/s12916-024-03389-w. BMC Med. 2024. PMID: 38658988
The combinational therapy could significantly increase the infiltration of CD4(+) T cells (P<0.05), CD25(+)CD4(+) T cells (P<0.001), and PD-1(+)CD8(+) T cells (P<0.05) compared to osimertinib. ScRNA-seq demonstrated that the number of CD8(+) T …
The combinational therapy could significantly increase the infiltration of CD4(+) T cells (P<0.05), CD25(+)CD4(+) T cells ( …
424,312 results
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