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Synthesis of Canthin-4-ones and Isocanthin-4-ones via B Ring Construction.
Koyioni M, Kourtellaris A, Koutentis PA. Koyioni M, et al. J Org Chem. 2024 Apr 24. doi: 10.1021/acs.joc.4c00440. Online ahead of print. J Org Chem. 2024. PMID: 38657206
Canthin-4-one is synthesized via a six-step procedure starting from commercially available 3-amino-4-bromopyridine in 26% overall yield. 3-Amino-4-bromopyridine is initially converted to 8-bromo-1,5-naphthyridin-4(1H)-one. O-Methylation, intermolecular Pd-catalyzed …
Canthin-4-one is synthesized via a six-step procedure starting from commercially available 3-amino-4-bromopyridine in 26% overall yield. 3-A …
Baroreflex dynamics during the rest to exercise transient in acute normobaric hypoxia in humans.
Taboni A, Fagoni N, Fontolliet T, Vinetti G, Ferretti G. Taboni A, et al. Eur J Appl Physiol. 2024 Apr 24. doi: 10.1007/s00421-024-05485-4. Online ahead of print. Eur J Appl Physiol. 2024. PMID: 38656378
METHODS: Ten participants performed three rest-to-50 W exercise transients on a cycle-ergometer in N (ambient air) and three in H (inspired fraction of O(2) = 0.11). R-to-R interval (RRi, by electrocardiography) and blood pressure profile (by photo-plethysmography) were re …
METHODS: Ten participants performed three rest-to-50 W exercise transients on a cycle-ergometer in N (ambient air) and three in H (inspired …
Effect of Laurus nobilis on bacteria and human transforming growth factor-β1.
Sancer O, Şahin U, Çetin ES, Tepebaşi MY, Cezaroğlu Y, Bilir G, Yünlü S, Koca A. Sancer O, et al. Rev Assoc Med Bras (1992). 2024 Apr 22;70(3):e20230683. doi: 10.1590/1806-9282.20230683. eCollection 2024. Rev Assoc Med Bras (1992). 2024. PMID: 38655992
The transforming growth factor-beta1 expression was analyzed using the RT-qPCR method. RESULTS: Epicatechin was found in the highest amount and o-coumaric acid in the lowest amount. The half-maximal inhibitory concentration (IC50) was determined to be 55.17 mug/mL. ...
The transforming growth factor-beta1 expression was analyzed using the RT-qPCR method. RESULTS: Epicatechin was found in the highest amount …
Modulatory potential of Bacopa monnieri against aflatoxin B1 induced biochemical, molecular and histological alterations in rats.
Rathour A, Gupte SS, Gupta D, Singh S, Shrivastava S, Yadav D, Shukla S. Rathour A, et al. Toxicol Res (Camb). 2024 Apr 21;13(2):tfae060. doi: 10.1093/toxres/tfae060. eCollection 2024 Apr. Toxicol Res (Camb). 2024. PMID: 38655144
This study was designed to explore the antioxidant activity of Bacopa monnieri (BM) on Aflatoxin B1 (AFB1) induced oxidative damage in Wistar albino rats. Aflatoxin B1 treatment (200 mug/kg/day, p.o.) for 28 days induced oxidative injury by a significant alteration in seru …
This study was designed to explore the antioxidant activity of Bacopa monnieri (BM) on Aflatoxin B1 (AFB1) induced oxidative damage in Wista …
Sex differences and dietary patterns in the association of air pollutants and hypertension.
Zhang C, Wang Y, Xie W, Zhang J, Tian T, Zhu Q, Fang X, Sui J, Pan D, Xia H, Wang S, Sun G, Dai Y. Zhang C, et al. BMC Public Health. 2024 Apr 23;24(1):1134. doi: 10.1186/s12889-024-18620-9. BMC Public Health. 2024. PMID: 38654317
The aim of this study was to investigate the sex-specific effects of dietary patterns on the association between fine particulate matter (PM(2.5)), ozone(O(3)) and hypertension in adults residing in Jiangsu Province of China. METHODS: A total of 3189 adults from the 2015 C …
The aim of this study was to investigate the sex-specific effects of dietary patterns on the association between fine particulate matter (PM …
Associations between long-term exposure to air pollution and kidney function utilizing electronic healthcare records: a cross-sectional study.
Dillon D, Ward-Caviness C, Kshirsagar AV, Moyer J, Schwartz J, Di Q, Weaver A. Dillon D, et al. Environ Health. 2024 Apr 23;23(1):43. doi: 10.1186/s12940-024-01080-4. Environ Health. 2024. PMID: 38654228
PM(2.5) and NO(2) data come from a hybrid model using 1 km(2) grids and O(3) data from 12 km(2) CMAQ grids. Exposure concentrations were 1-year averages. ...CONCLUSIONS: One-year average PM(2.5) was associated with reduced eGFR(cr), while O(3) and NO(2) were inverse …
PM(2.5) and NO(2) data come from a hybrid model using 1 km(2) grids and O(3) data from 12 km(2) CMAQ grids. Exposure concentrations w …
Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson's disease pathology.
Kim DY, Kim SM, Cho EJ, Kwak HB, Han IO. Kim DY, et al. Cell Death Dis. 2024 Apr 23;15(4):287. doi: 10.1038/s41419-024-06670-1. Cell Death Dis. 2024. PMID: 38654003
This study aimed to elucidate the role of O-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like neurodegeneration and the underlying mechanisms. ...Interestingly, elevating O-GlcNAcylation through glucosamine (GlcN) injection pr …
This study aimed to elucidate the role of O-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like …
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