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A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
Stops AJ, Heraty KB, Browne M, O'Brien FJ, McHugh PE. Stops AJ, et al. J Biomech. 2010 Mar 3;43(4):618-26. doi: 10.1016/j.jbiomech.2009.10.037. Epub 2009 Nov 25. J Biomech. 2010. PMID: 19939388
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
Stops AJ, Harrison NM, Haugh MG, O'Brien FJ, McHugh PE. Stops AJ, et al. J Mech Behav Biomed Mater. 2010 May;3(4):292-302. doi: 10.1016/j.jmbbm.2009.12.003. Epub 2010 Jan 6. J Mech Behav Biomed Mater. 2010. PMID: 20346897
The effect of pore size on cell adhesion in collagen-GAG scaffolds.
O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. O'Brien FJ, et al. Biomaterials. 2005 Feb;26(4):433-41. doi: 10.1016/j.biomaterials.2004.02.052. Biomaterials. 2005. PMID: 15275817
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
Farrell E, Byrne EM, Fischer J, O'Brien FJ, O'Connell BC, Prendergast PJ, Campbell VA. Farrell E, et al. Technol Health Care. 2007;15(1):19-31. Technol Health Care. 2007. PMID: 17264410
The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.
McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy JM, Barry FP, Guldberg RE, O'Brien FJ. McFadden TM, et al. Acta Biomater. 2013 Dec;9(12):9303-16. doi: 10.1016/j.actbio.2013.08.014. Epub 2013 Aug 17. Acta Biomater. 2013. PMID: 23958783
Evaluation of the ability of collagen-glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats.
Alhag M, Farrell E, Toner M, Lee TC, O'Brien FJ, Claffey N. Alhag M, et al. Oral Maxillofac Surg. 2012 Mar;16(1):47-55. doi: 10.1007/s10006-011-0299-0. Epub 2011 Oct 4. Oral Maxillofac Surg. 2012. PMID: 21968608
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model.
Jungreuthmayer C, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ. Jungreuthmayer C, et al. Med Eng Phys. 2009 May;31(4):420-7. doi: 10.1016/j.medengphy.2008.11.003. Epub 2008 Dec 23. Med Eng Phys. 2009. PMID: 19109048
Biomechanics and mechanobiology in osteochondral tissues.
McMahon LA, O'Brien FJ, Prendergast PJ. McMahon LA, et al. Regen Med. 2008 Sep;3(5):743-59. doi: 10.2217/17460751.3.5.743. Regen Med. 2008. PMID: 18729798 Review.
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
Thorpe SD, Buckley CT, Vinardell T, O'Brien FJ, Campbell VA, Kelly DJ. Thorpe SD, et al. Biochem Biophys Res Commun. 2008 Dec 12;377(2):458-462. doi: 10.1016/j.bbrc.2008.09.154. Epub 2008 Oct 11. Biochem Biophys Res Commun. 2008. PMID: 18851955
Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep.
Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ. Brennan O, et al. J Biomech. 2009 Mar 11;42(4):498-503. doi: 10.1016/j.jbiomech.2008.11.032. Epub 2009 Jan 25. J Biomech. 2009. PMID: 19171344
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