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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.
Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF. Muttenthaler M, et al. Sci Signal. 2017 Dec 5;10(508):eaan3398. doi: 10.1126/scisignal.aan3398. Sci Signal. 2017. PMID: 29208680 Free PMC article.
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.
Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW. Koehbach J, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21183-8. doi: 10.1073/pnas.1311183110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248349 Free PMC article.
Uterotonic plants and their bioactive constituents.
Gruber CW, O'Brien M. Gruber CW, et al. Planta Med. 2011 Feb;77(3):207-20. doi: 10.1055/s-0030-1250317. Epub 2010 Sep 15. Planta Med. 2011. PMID: 20845261 Free PMC article. Review.
Ghrelin in the human myometrium.
O'Brien M, Earley P, Morrison JJ, Smith TJ. O'Brien M, et al. Reprod Biol Endocrinol. 2010 May 28;8:55. doi: 10.1186/1477-7827-8-55. Reprod Biol Endocrinol. 2010. PMID: 20509935 Free PMC article.
3,310 results