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The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination.
Oldham CE, Mohney RP, Miller SL, Hanes RN, O'Bryan JP. Oldham CE, et al. Curr Biol. 2002 Jul 9;12(13):1112-6. doi: 10.1016/s0960-9822(02)00900-4. Curr Biol. 2002. PMID: 12121618
The PTB domain: a modular domain with multiple function.
O'Bryan JP. O'Bryan JP. Curr Opin Drug Discov Devel. 1999 Sep;2(5):505-18. Curr Opin Drug Discov Devel. 1999. PMID: 19649978
Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin.
Miller SL, Scappini EL, O'Bryan J. Miller SL, et al. J Biol Chem. 2007 Mar 30;282(13):10096-103. doi: 10.1074/jbc.M611151200. Epub 2007 Feb 2. J Biol Chem. 2007. PMID: 17276991
Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation.
Miller SL, Malotky E, O'Bryan JP. Miller SL, et al. J Biol Chem. 2004 Aug 6;279(32):33528-37. doi: 10.1074/jbc.M313097200. Epub 2004 May 21. J Biol Chem. 2004. PMID: 15155768
Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway.
Das M, Scappini E, Martin NP, Wong KA, Dunn S, Chen YJ, Miller SL, Domin J, O'Bryan JP. Das M, et al. Mol Cell Biol. 2007 Nov;27(22):7906-17. doi: 10.1128/MCB.01369-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875942 Free PMC article.
Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.
Scappini E, Koh TW, Martin NP, O'Bryan JP. Scappini E, et al. Hum Mol Genet. 2007 Aug 1;16(15):1862-71. doi: 10.1093/hmg/ddm134. Epub 2007 Jun 5. Hum Mol Genet. 2007. PMID: 17550941
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
Martin NP, Mohney RP, Dunn S, Das M, Scappini E, O'Bryan JP. Martin NP, et al. Mol Pharmacol. 2006 Nov;70(5):1643-53. doi: 10.1124/mol.106.028274. Epub 2006 Aug 16. Mol Pharmacol. 2006. PMID: 16914641
The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin.
Timsit YE, Miller SL, Mohney RP, O'Bryan JP. Timsit YE, et al. Biochem Biophys Res Commun. 2005 Mar 11;328(2):550-9. doi: 10.1016/j.bbrc.2005.01.022. Biochem Biophys Res Commun. 2005. PMID: 15694383
Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.
Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP. Mohney RP, et al. J Biol Chem. 2003 Nov 21;278(47):47038-45. doi: 10.1074/jbc.M303895200. Epub 2003 Sep 11. J Biol Chem. 2003. PMID: 12970366
Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel.
Storey NM, O'Bryan JP, Armstrong DL. Storey NM, et al. Curr Biol. 2002 Jan 8;12(1):27-33. doi: 10.1016/s0960-9822(01)00625-x. Curr Biol. 2002. PMID: 11790300
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