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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Lachner M, et al. Nature. 2001 Mar 1;410(6824):116-20. doi: 10.1038/35065132. Nature. 2001. PMID: 11242053
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.
Laible G, Haynes AR, Lebersorger A, O'Carroll D, Mattei MG, Denny P, Brown SD, Jenuwein T. Laible G, et al. Mamm Genome. 1999 Mar;10(3):311-4. doi: 10.1007/s003359900993. Mamm Genome. 1999. PMID: 10051331 No abstract available.
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T. Rea S, et al. Nature. 2000 Aug 10;406(6796):593-9. doi: 10.1038/35020506. Nature. 2000. PMID: 10949293
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T. O'Carroll D, et al. Mol Cell Biol. 2000 Dec;20(24):9423-33. doi: 10.1128/mcb.20.24.9423-9433.2000. Mol Cell Biol. 2000. PMID: 11094092 Free PMC article.
The polycomb-group gene Ezh2 is required for early mouse development.
O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T. O'Carroll D, et al. Mol Cell Biol. 2001 Jul;21(13):4330-6. doi: 10.1128/MCB.21.13.4330-4336.2001. Mol Cell Biol. 2001. PMID: 11390661 Free PMC article.
Rb targets histone H3 methylation and HP1 to promoters.
Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE, Kouzarides T. Nielsen SJ, et al. Nature. 2001 Aug 2;412(6846):561-5. doi: 10.1038/35087620. Nature. 2001. PMID: 11484059
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schöfer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T. Peters AH, et al. Cell. 2001 Nov 2;107(3):323-37. doi: 10.1016/s0092-8674(01)00542-6. Cell. 2001. PMID: 11701123
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.
Peters AH, Mermoud JE, O'Carroll D, Pagani M, Schweizer D, Brockdorff N, Jenuwein T. Peters AH, et al. Nat Genet. 2002 Jan;30(1):77-80. doi: 10.1038/ng789. Epub 2001 Dec 10. Nat Genet. 2002. PMID: 11740497
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.
Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C. Lagger G, et al. EMBO J. 2002 Jun 3;21(11):2672-81. doi: 10.1093/emboj/21.11.2672. EMBO J. 2002. PMID: 12032080 Free PMC article.
Blimp1 is a critical determinant of the germ cell lineage in mice.
Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA. Ohinata Y, et al. Nature. 2005 Jul 14;436(7048):207-13. doi: 10.1038/nature03813. Epub 2005 Jun 5. Nature. 2005. PMID: 15937476
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