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Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.
O'Connell MP, Weeraratna AT. O'Connell MP, et al. Pigment Cell Melanoma Res. 2009 Dec;22(6):724-39. doi: 10.1111/j.1755-148X.2009.00627.x. Epub 2009 Aug 25. Pigment Cell Melanoma Res. 2009. PMID: 19708915 Free PMC article. Review.
Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.
O'Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, Indig FE, Flaherty KT, Wargo JA, Frederick DT, Cooper ZA, Nair S, Amaravadi RK, Schuchter LM, Karakousis GC, Xu W, Xu X, Weeraratna AT. O'Connell MP, et al. Cancer Discov. 2013 Dec;3(12):1378-93. doi: 10.1158/2159-8290.CD-13-0005. Epub 2013 Oct 8. Cancer Discov. 2013. PMID: 24104062 Free PMC article.
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT. Dissanayake SK, et al. J Biol Chem. 2007 Jun 8;282(23):17259-71. doi: 10.1074/jbc.M700075200. Epub 2007 Apr 10. J Biol Chem. 2007. PMID: 17426020 Free PMC article.
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT. Dissanayake SK, et al. Cancer Res. 2008 Dec 15;68(24):10205-14. doi: 10.1158/0008-5472.CAN-08-2149. Cancer Res. 2008. PMID: 19074888 Free PMC article.
Assaying Wnt5A-mediated invasion in melanoma cells.
O'Connell MP, French AD, Leotlela PD, Weeraratna AT. O'Connell MP, et al. Methods Mol Biol. 2008;468:243-53. doi: 10.1007/978-1-59745-249-6_19. Methods Mol Biol. 2008. PMID: 19099260 Free PMC article.
Wnt5A activates the calpain-mediated cleavage of filamin A.
O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT. O'Connell MP, et al. J Invest Dermatol. 2009 Jul;129(7):1782-9. doi: 10.1038/jid.2008.433. Epub 2009 Jan 29. J Invest Dermatol. 2009. PMID: 19177143 Free PMC article.
121 results