O'Connor JC - Search Results

1

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.

Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG. Hartman ME, et al. J Biol Chem. 2004 Jul 2;279(27):28045-50. doi: 10.1074/jbc.M404368200. Epub 2004 Apr 27. J Biol Chem. 2004. PMID: 15123681 Free article.

2

Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake.

O'Connor JC, Freund GG. O'Connor JC, et al. Metabolism. 2003 Jun;52(6):666-74. doi: 10.1016/s0026-0495(03)00026-x. Metabolism. 2003. PMID: 12800089

3

Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK.

Sherry CL, O'Connor JC, Kramer JM, Freund GG. Sherry CL, et al. J Immunol. 2007 Jan 15;178(2):663-70. doi: 10.4049/jimmunol.178.2.663. J Immunol. 2007. PMID: 17202326

4

Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3.

O'Connor JC, Sherry CL, Guest CB, Freund GG. O'Connor JC, et al. J Immunol. 2007 Jun 1;178(11):6886-93. doi: 10.4049/jimmunol.178.11.6886. J Immunol. 2007. PMID: 17513737

5

Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle.

Baum JI, O'Connor JC, Seyler JE, Anthony TG, Freund GG, Layman DK. Baum JI, et al. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E86-91. doi: 10.1152/ajpendo.00272.2004. Epub 2004 Aug 31. Am J Physiol Endocrinol Metab. 2005. PMID: 15339747 Free article.

6

IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes.

O'Connor JC, Satpathy A, Hartman ME, Horvath EM, Kelley KW, Dantzer R, Johnson RW, Freund GG. O'Connor JC, et al. J Immunol. 2005 Apr 15;174(8):4991-7. doi: 10.4049/jimmunol.174.8.4991. J Immunol. 2005. PMID: 15814729

7

Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness.

Johnson DR, O'Connor JC, Dantzer R, Freund GG. Johnson DR, et al. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15184-9. doi: 10.1073/pnas.0507191102. Epub 2005 Oct 10. Proc Natl Acad Sci U S A. 2005. PMID: 16217019 Free PMC article.

8

Psychoneuroimmune implications of type 2 diabetes.

O'Connor JC, Johnson DR, Freund GG. O'Connor JC, et al. Neurol Clin. 2006 Aug;24(3):539-59. doi: 10.1016/j.ncl.2006.03.001. Neurol Clin. 2006. PMID: 16877123 Review.

9

Cytokines in type 2 diabetes.

Johnson DR, O'Connor JC, Satpathy A, Freund GG. Johnson DR, et al. Vitam Horm. 2006;74:405-41. doi: 10.1016/S0083-6729(06)74017-1. Vitam Horm. 2006. PMID: 17027525 Review. No abstract available.

10

Acute hypoxia activates the neuroimmune system, which diabetes exacerbates.

Johnson DR, O'Connor JC, Hartman ME, Tapping RI, Freund GG. Johnson DR, et al. J Neurosci. 2007 Jan 31;27(5):1161-6. doi: 10.1523/JNEUROSCI.4560-06.2007. J Neurosci. 2007. PMID: 17267571 Free PMC article.

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