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Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells.
Aldrovandi M, Banthiya S, Meckelmann S, Zhou Y, Heydeck D, O'Donnell VB, Kuhn H. Aldrovandi M, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):152-164. doi: 10.1016/j.bbalip.2017.11.005. Epub 2017 Nov 14. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 29146531 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
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