O'Donovan SD - Search Results

1

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator.

O'Donovan SD, Lenz M, Goossens GH, van der Kallen CJH, Eussen SJMP, Stehouwer CDA, van Greevenbroek MM, Schram MT, Sep SJ, Peeters RLM, Blaak EE, van Riel NAW, de Kok TMCM, Arts ICW. O'Donovan SD, et al. Sci Rep. 2019 Jun 28;9(1):9388. doi: 10.1038/s41598-019-45858-w. Sci Rep. 2019. PMID: 31253846 Free PMC article.

2

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data.

O'Donovan SD, Lenz M, Vink RG, Roumans NJT, de Kok TMCM, Mariman ECM, Peeters RLM, van Riel NAW, van Baak MA, Arts ICW. O'Donovan SD, et al. PLoS Comput Biol. 2019 Oct 3;15(10):e1007400. doi: 10.1371/journal.pcbi.1007400. eCollection 2019 Oct. PLoS Comput Biol. 2019. PMID: 31581241 Free PMC article.

3

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes.

O'Donovan SD, Driessens K, Lopatta D, Wimmenauer F, Lukas A, Neeven J, Stumm T, Smirnov E, Lenz M, Ertaylan G, Jennen DGJ, van Riel NAW, Cavill R, Peeters RLM, de Kok TMCM. O'Donovan SD, et al. PLoS One. 2020 Aug 11;15(8):e0236392. doi: 10.1371/journal.pone.0236392. eCollection 2020. PLoS One. 2020. PMID: 32780735 Free PMC article.

4

Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge.

Erdős B, van Sloun B, Adriaens ME, O'Donovan SD, Langin D, Astrup A, Blaak EE, Arts ICW, van Riel NAW. Erdős B, et al. Among authors: o donovan sd. PLoS Comput Biol. 2021 Mar 31;17(3):e1008852. doi: 10.1371/journal.pcbi.1008852. eCollection 2021 Mar. PLoS Comput Biol. 2021. PMID: 33788828 Free PMC article.

5

Quantifying the contribution of triglycerides to metabolic resilience through the mixed meal model.

O'Donovan SD, Erdős B, Jacobs DM, Wanders AJ, Thomas EL, Bell JD, Rundle M, Frost G, Arts ICW, Afman LA, van Riel NAW. O'Donovan SD, et al. iScience. 2022 Oct 3;25(11):105206. doi: 10.1016/j.isci.2022.105206. eCollection 2022 Nov 18. iScience. 2022. PMID: 36281448 Free PMC article.

6

E-DES-PROT: A novel computational model to describe the effects of amino acids and protein on postprandial glucose and insulin dynamics in humans.

van Sloun B, Goossens GH, Erdõs B, O'Donovan SD, Singh-Povel CM, Geurts JMW, van Riel NAW, Arts ICW. van Sloun B, et al. Among authors: o donovan sd. iScience. 2023 Feb 18;26(3):106218. doi: 10.1016/j.isci.2023.106218. eCollection 2023 Mar 17. iScience. 2023. PMID: 36895641 Free PMC article.

7

Analysis of high-dimensional metabolomics data with complex temporal dynamics using RM-ASCA.

Erdős B, Westerhuis JA, Adriaens ME, O'Donovan SD, Xie R, Singh-Povel CM, Smilde AK, Arts ICW. Erdős B, et al. Among authors: o donovan sd. PLoS Comput Biol. 2023 Jun 23;19(6):e1011221. doi: 10.1371/journal.pcbi.1011221. eCollection 2023 Jun. PLoS Comput Biol. 2023. PMID: 37352364 Free PMC article.

8

Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study.

Erdős B, van Sloun B, Goossens GH, O'Donovan SD, de Galan BE, van Greevenbroek MMJ, Stehouwer CDA, Schram MT, Blaak EE, Adriaens ME, van Riel NAW, Arts ICW. Erdős B, et al. Among authors: o donovan sd. PLoS One. 2023 Jul 27;18(7):e0285820. doi: 10.1371/journal.pone.0285820. eCollection 2023. PLoS One. 2023. PMID: 37498860 Free PMC article.

9

Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data.

O'Donovan SD, Cavill R, Wimmenauer F, Lukas A, Stumm T, Smirnov E, Lenz M, Ertaylan G, Jennen DGJ, van Riel NAW, Driessens K, Peeters RLM, de Kok TMCM. O'Donovan SD, et al. PLoS One. 2023 Nov 30;18(11):e0292030. doi: 10.1371/journal.pone.0292030. eCollection 2023. PLoS One. 2023. PMID: 38032940 Free PMC article.

10

Quantifying the effect of nutritional interventions on metabolic resilience using personalized computational models.

O'Donovan SD, Rundle M, Thomas EL, Bell JD, Frost G, Jacobs DM, Wanders A, de Vries R, Mariman ECM, van Baak MA, Sterkman L, Nieuwdorp M, Groen AK, Arts ICW, van Riel NAW, Afman LA. O'Donovan SD, et al. iScience. 2024 Feb 29;27(4):109362. doi: 10.1016/j.isci.2024.109362. eCollection 2024 Apr 19. iScience. 2024. PMID: 38500825 Free PMC article.

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