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Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity.
Lee DK, George SR, O'Dowd BF. Lee DK, et al. Trends Pharmacol Sci. 2006 Apr;27(4):190-4. doi: 10.1016/j.tips.2006.02.006. Epub 2006 Mar 13. Trends Pharmacol Sci. 2006. PMID: 16530855 Review.
A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism.
Hasbi A, Perreault ML, Shen MY, Zhang L, To R, Fan T, Nguyen T, Ji X, O'Dowd BF, George SR. Hasbi A, et al. Among authors: o dowd bf. FASEB J. 2014 Nov;28(11):4806-20. doi: 10.1096/fj.14-254037. Epub 2014 Jul 25. FASEB J. 2014. PMID: 25063849 Free PMC article.
Dopamine receptor homooligomers and heterooligomers in schizophrenia.
Perreault ML, O'Dowd BF, George SR. Perreault ML, et al. CNS Neurosci Ther. 2011 Feb;17(1):52-7. doi: 10.1111/j.1755-5949.2010.00228.x. Epub 2010 Dec 28. CNS Neurosci Ther. 2011. PMID: 21199449 Free PMC article. Review.
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.
Lee DK, Ferguson SS, George SR, O'Dowd BF. Lee DK, et al. Biochem Biophys Res Commun. 2010 Apr 30;395(2):185-9. doi: 10.1016/j.bbrc.2010.03.151. Epub 2010 Mar 28. Biochem Biophys Res Commun. 2010. PMID: 20353754
Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms.
Hasbi A, O'Dowd BF, George SR. Hasbi A, et al. Curr Opin Pharmacol. 2010 Feb;10(1):93-9. doi: 10.1016/j.coph.2009.09.011. Epub 2009 Nov 10. Curr Opin Pharmacol. 2010. PMID: 19897420 Free PMC article. Review.
Modification of the terminal residue of apelin-13 antagonizes its hypotensive action.
Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Lee DK, et al. Endocrinology. 2005 Jan;146(1):231-6. doi: 10.1210/en.2004-0359. Epub 2004 Oct 14. Endocrinology. 2005. PMID: 15486224
Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance.
Perreault ML, Hasbi A, O'Dowd BF, George SR. Perreault ML, et al. Among authors: o dowd bf. Neuropsychopharmacology. 2014 Jan;39(1):156-68. doi: 10.1038/npp.2013.148. Epub 2013 Jun 18. Neuropsychopharmacology. 2014. PMID: 23774533 Free PMC article. Review.
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance.
Hasbi A, O'Dowd BF, George SR. Hasbi A, et al. Mol Brain. 2011 Jun 13;4:26. doi: 10.1186/1756-6606-4-26. Mol Brain. 2011. PMID: 21663703 Free PMC article.
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Seeman P, Weinshenker D, Quirion R, Srivastava LK, Bhardwaj SK, Grandy DK, Premont RT, Sotnikova TD, Boksa P, El-Ghundi M, O'dowd BF, George SR, Perreault ML, Männistö PT, Robinson S, Palmiter RD, Tallerico T. Seeman P, et al. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3513-8. doi: 10.1073/pnas.0409766102. Epub 2005 Feb 16. Proc Natl Acad Sci U S A. 2005. PMID: 15716360 Free PMC article.
Novel human G-protein-coupled receptors.
Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Vanti WB, et al. Biochem Biophys Res Commun. 2003 May 23;305(1):67-71. doi: 10.1016/s0006-291x(03)00709-5. Biochem Biophys Res Commun. 2003. PMID: 12732197
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