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Global analysis of fungal morphology exposes mechanisms of host cell escape.
O'Meara TR, Veri AO, Ketela T, Jiang B, Roemer T, Cowen LE. O'Meara TR, et al. Nat Commun. 2015 Mar 31;6:6741. doi: 10.1038/ncomms7741. Nat Commun. 2015. PMID: 25824284 Free PMC article.
The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.
O'Meara TR, Xu W, Selvig KM, O'Meara MJ, Mitchell AP, Alspaugh JA. O'Meara TR, et al. Mol Cell Biol. 2014 Feb;34(4):673-84. doi: 10.1128/MCB.01359-13. Epub 2013 Dec 9. Mol Cell Biol. 2014. PMID: 24324006 Free PMC article.
Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.
Polvi EJ, Li X, O'Meara TR, Leach MD, Cowen LE. Polvi EJ, et al. Cell Mol Life Sci. 2015 Jun;72(12):2261-87. doi: 10.1007/s00018-015-1860-z. Epub 2015 Feb 21. Cell Mol Life Sci. 2015. PMID: 25700837 Review.
Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress.
O'Meara TR, Veri AO, Polvi EJ, Li X, Valaei SF, Diezmann S, Cowen LE. O'Meara TR, et al. PLoS Genet. 2016 Jun 24;12(6):e1006142. doi: 10.1371/journal.pgen.1006142. eCollection 2016 Jun. PLoS Genet. 2016. PMID: 27341673 Free PMC article.
Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.
Li X, Robbins N, O'Meara TR, Cowen LE. Li X, et al. Mol Microbiol. 2017 Feb;103(4):635-656. doi: 10.1111/mmi.13578. Epub 2016 Dec 14. Mol Microbiol. 2017. PMID: 27868254 Free PMC article.
Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.
Xie JL, O'Meara TR, Polvi EJ, Robbins N, Cowen LE. Xie JL, et al. mSphere. 2017 Mar 1;2(2):e00056-17. doi: 10.1128/mSphere.00056-17. eCollection 2017 Mar-Apr. mSphere. 2017. PMID: 28261668 Free PMC article.
The Hsp90 Chaperone Network Modulates Candida Virulence Traits.
O'Meara TR, Robbins N, Cowen LE. O'Meara TR, et al. Trends Microbiol. 2017 Oct;25(10):809-819. doi: 10.1016/j.tim.2017.05.003. Epub 2017 May 23. Trends Microbiol. 2017. PMID: 28549824 Free PMC article. Review.
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