O'Neil M - Search Results

1

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

Spring M, Murphy J, Nielsen R, Dowler M, Bennett JW, Zarling S, Williams J, de la Vega P, Ware L, Komisar J, Polhemus M, Richie TL, Epstein J, Tamminga C, Chuang I, Richie N, O'Neil M, Heppner DG, Healer J, O'Neill M, Smithers H, Finney OC, Mikolajczak SA, Wang R, Cowman A, Ockenhouse C, Krzych U, Kappe SH. Spring M, et al. Vaccine. 2013 Oct 9;31(43):4975-83. doi: 10.1016/j.vaccine.2013.08.007. Epub 2013 Sep 8. Vaccine. 2013. PMID: 24029408 Clinical Trial.

2

Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.

Milner E, Sousa J, Pybus B, Auschwitz J, Caridha D, Gardner S, Grauer K, Harris E, Hickman M, Kozar MP, Lee P, Leed S, Li Q, Melendez V, Moon J, Ngundam F, O'Neil M, Parriott S, Potter B, Sciotti R, Tangteung A, Dow GS. Milner E, et al. Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):17-22. doi: 10.1007/s13318-012-0080-2. Eur J Drug Metab Pharmacokinet. 2012. PMID: 22314893

3

Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections.

Li Q, O'Neil M, Xie L, Caridha D, Zeng Q, Zhang J, Pybus B, Hickman M, Melendez V. Li Q, et al. Malar J. 2014 Apr 14;13:141. doi: 10.1186/1475-2875-13-141. Malar J. 2014. PMID: 24731238 Free PMC article.

4

Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives.

Liu X, Wang X, Li Q, Kozar MP, Melendez V, O'Neil MT, Lin AJ. Liu X, et al. J Med Chem. 2011 Jul 14;54(13):4523-35. doi: 10.1021/jm200111g. Epub 2011 May 31. J Med Chem. 2011. PMID: 21627120

5

Synthesis and In vitro Efficacy of Tetracyclic Benzothiazepines Against Blood-Stage Plasmodium falciparum and Liver-Stage P. berghei.

Gutteridge CE, Sadowski BW, Hughes SM, Friedlander JA, Gaidry AD, Baxter MC, Smith MB, Rodrigo LG, O'Neil MT, Gerena L, Lee PJ, Sathunuru R, Gettayacamin M. Gutteridge CE, et al. Med Chem. 2023;19(5):478-484. doi: 10.2174/1573406418666220820112324. Med Chem. 2023. PMID: 35993460

6

Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives.

Guan J, Zhang Q, O'Neil M, Obaldia N 3rd, Ager A, Gerena L, Lin AJ. Guan J, et al. Antimicrob Agents Chemother. 2005 Dec;49(12):4928-33. doi: 10.1128/AAC.49.12.4928-4933.2005. Antimicrob Agents Chemother. 2005. PMID: 16304154 Free PMC article.

7

Antimalarial activities of new guanidylimidazole and guanidylimidazoline derivatives.

Zhang L, Sathunuru R, Caridha D, Pybus B, O'Neil MT, Kozar MP, Lin AJ. Zhang L, et al. J Med Chem. 2011 Oct 13;54(19):6634-46. doi: 10.1021/jm200503s. Epub 2011 Sep 2. J Med Chem. 2011. PMID: 21848332

8

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus.

Jirage D, Chen Y, Caridha D, O'Neil MT, Eyase F, Witola WH, Mamoun CB, Waters NC. Jirage D, et al. Mol Biochem Parasitol. 2010 Jul;172(1):9-18. doi: 10.1016/j.molbiopara.2010.03.009. Epub 2010 Mar 21. Mol Biochem Parasitol. 2010. PMID: 20332005

9

In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.

Shearer TW, Kozar MP, O'Neil MT, Smith PL, Schiehser GA, Jacobus DP, Diaz DS, Yang YS, Milhous WK, Skillman DR. Shearer TW, et al. J Med Chem. 2005 Apr 21;48(8):2805-13. doi: 10.1021/jm049683+. J Med Chem. 2005. PMID: 15828818

10

A novel Plasmodium falciparum expression system for assessing antifolate resistance caused by mutant P. vivax dihydrofolate reductase-thymidylate synthase.

O'Neil MT, Korsinczky ML, Gresty KJ, Auliff A, Cheng Q. O'Neil MT, et al. J Infect Dis. 2007 Aug 1;196(3):467-74. doi: 10.1086/519286. Epub 2007 Jun 20. J Infect Dis. 2007. PMID: 17597462

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