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Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.
Koukouli F, Rooy M, Tziotis D, Sailor KA, O'Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U. Koukouli F, et al. Nat Med. 2017 Mar;23(3):347-354. doi: 10.1038/nm.4274. Epub 2017 Jan 23. Nat Med. 2017. PMID: 28112735 Free PMC article.
Habenular TCF7L2 links nicotine addiction to diabetes.
Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Duncan A, et al. Nature. 2019 Oct;574(7778):372-377. doi: 10.1038/s41586-019-1653-x. Epub 2019 Oct 16. Nature. 2019. PMID: 31619789 Free PMC article.
Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. O'Neill HC, et al. Pharmacol Biochem Behav. 2013 Jan;103(3):603-21. doi: 10.1016/j.pbb.2012.10.014. Epub 2012 Nov 1. Pharmacol Biochem Behav. 2013. PMID: 23123803 Free PMC article.
179 results