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136 results
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Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
Altmann KH, Wartmann M, O'Reilly T. Altmann KH, et al. Biochim Biophys Acta. 2000 May 17;1470(3):M79-91. doi: 10.1016/s0304-419x(00)00009-3. Biochim Biophys Acta. 2000. PMID: 10799747 Review. No abstract available.
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Brüggen J, O'Reilly T, Flörsheimer A. Blum W, et al. Rapid Commun Mass Spectrom. 2001;15(1):41-9. doi: 10.1002/1097-0231(20010115)15:1<41::AID-RCM190>3.0.CO;2-W. Rapid Commun Mass Spectrom. 2001. PMID: 11135423
Tyrosine kinase inhibitors: from rational design to clinical trials.
Traxler P, Bold G, Buchdunger E, Caravatti G, Furet P, Manley P, O'Reilly T, Wood J, Zimmermann J. Traxler P, et al. Med Res Rev. 2001 Nov;21(6):499-512. doi: 10.1002/med.1022. Med Res Rev. 2001. PMID: 11607931 Review.
PKC412--a protein kinase inhibitor with a broad therapeutic potential.
Fabbro D, Ruetz S, Bodis S, Pruschy M, Csermak K, Man A, Campochiaro P, Wood J, O'Reilly T, Meyer T. Fabbro D, et al. Anticancer Drug Des. 2000 Feb;15(1):17-28. Anticancer Drug Des. 2000. PMID: 10888033
Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent.
Fabbro D, Buchdunger E, Wood J, Mestan J, Hofmann F, Ferrari S, Mett H, O'Reilly T, Meyer T. Fabbro D, et al. Pharmacol Ther. 1999 May-Jun;82(2-3):293-301. doi: 10.1016/s0163-7258(99)00005-4. Pharmacol Ther. 1999. PMID: 10454207 Review.
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rösel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister G, Schirner M, Thierauch KH, Schneider MR, Drevs J, Martiny-Baron G, Totzke F. Wood JM, et al. Cancer Res. 2000 Apr 15;60(8):2178-89. Cancer Res. 2000. PMID: 10786682
Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits.
Dumont RA, Car BD, Voitenok NN, Junker U, Moser B, Zak O, O'Reilly T. Dumont RA, et al. Infect Immun. 2000 Oct;68(10):5756-63. doi: 10.1128/iai.68.10.5756-5763.2000. Infect Immun. 2000. PMID: 10992482 Free PMC article.
Effect of combination therapy of rifampicin and azithromycin on TNF levels during a rat model of chronic osteomyelitis.
Littlewood-Evans AJ, Hattenberger M, Zak O, O'Reilly T. Littlewood-Evans AJ, et al. J Antimicrob Chemother. 1997 Apr;39(4):493-8. doi: 10.1093/jac/39.4.493. J Antimicrob Chemother. 1997. PMID: 9145822
Relationship between antibiotic concentration in bone and efficacy of treatment of staphylococcal osteomyelitis in rats: azithromycin compared with clindamycin and rifampin.
O'Reilly T, Kunz S, Sande E, Zak O, Sande MA, Täuber MG. O'Reilly T, et al. Antimicrob Agents Chemother. 1992 Dec;36(12):2693-7. doi: 10.1128/aac.36.12.2693. Antimicrob Agents Chemother. 1992. PMID: 1336342 Free PMC article.
Unique chemical reactivity of His-21 of CRM-197, a mutated diphtheria toxin.
Chang JY, Ramseier U, Hawthorne T, O'Reilly T, van Oostrum J. Chang JY, et al. FEBS Lett. 1998 May 15;427(3):362-6. doi: 10.1016/s0014-5793(98)00474-8. FEBS Lett. 1998. PMID: 9637258
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