O'Rourke K - Search Results

1

The ubiquitin ligase COP1 is a critical negative regulator of p53.

Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM. Dornan D, et al. Nature. 2004 May 6;429(6987):86-92. doi: 10.1038/nature02514. Epub 2004 Apr 21. Nature. 2004. PMID: 15103385

2

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Wertz IE, et al. Science. 2004 Feb 27;303(5662):1371-4. doi: 10.1126/science.1093549. Epub 2004 Jan 22. Science. 2004. PMID: 14739464 Free article.

3

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. Wertz IE, et al. Nature. 2004 Aug 5;430(7000):694-9. doi: 10.1038/nature02794. Epub 2004 Jul 18. Nature. 2004. PMID: 15258597

4

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM. Pereg Y, et al. Nat Cell Biol. 2010 Apr;12(4):400-6. doi: 10.1038/ncb2041. Epub 2010 Mar 14. Nat Cell Biol. 2010. PMID: 20228808

5

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM. Wertz IE, et al. Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Nature. 2011. PMID: 21368834

6

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM. Zhou H, et al. Nature. 2004 Jan 8;427(6970):167-71. doi: 10.1038/nature02273. Epub 2003 Dec 24. Nature. 2004. PMID: 14695475

7

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.

Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'rourke K, Seshagiri S, Dixit VM. Dornan D, et al. Science. 2006 Aug 25;313(5790):1122-6. doi: 10.1126/science.1127335. Science. 2006. PMID: 16931761

8

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.

Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM. Schwickart M, et al. Nature. 2010 Jan 7;463(7277):103-7. doi: 10.1038/nature08646. Epub 2009 Dec 20. Nature. 2010. PMID: 20023629

9

COP1 is a tumour suppressor that causes degradation of ETS transcription factors.

Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM. Vitari AC, et al. Nature. 2011 May 15;474(7351):403-6. doi: 10.1038/nature10005. Nature. 2011. PMID: 21572435

10

DUBA: a deubiquitinase that regulates type I interferon production.

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. Kayagaki N, et al. Science. 2007 Dec 7;318(5856):1628-32. doi: 10.1126/science.1145918. Epub 2007 Nov 8. Science. 2007. PMID: 17991829

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