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Posttranscriptional control of T cell effector function by aerobic glycolysis.
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Chang CH, et al. Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016. Cell. 2013. PMID: 23746840 Free PMC article.
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.
van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. van der Windt GJ, et al. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940348 Free PMC article.
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ. Huang SC, et al. Nat Immunol. 2014 Sep;15(9):846-55. doi: 10.1038/ni.2956. Epub 2014 Aug 3. Nat Immunol. 2014. PMID: 25086775 Free PMC article.
Targeting T cell metabolism for therapy.
O'Sullivan D, Pearce EL. O'Sullivan D, et al. Trends Immunol. 2015 Feb;36(2):71-80. doi: 10.1016/j.it.2014.12.004. Epub 2015 Jan 15. Trends Immunol. 2015. PMID: 25601541 Free PMC article. Review.
T cell metabolism drives immunity.
Buck MD, O'Sullivan D, Pearce EL. Buck MD, et al. J Exp Med. 2015 Aug 24;212(9):1345-60. doi: 10.1084/jem.20151159. Epub 2015 Aug 10. J Exp Med. 2015. PMID: 26261266 Free PMC article. Review.
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Buck MD, et al. Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9. Cell. 2016. PMID: 27293185 Free PMC article.
1,019 results