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Page 1
Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder.
Alonso P, Gratacós M, Segalàs C, Escaramís G, Real E, Bayés M, Labad J, López-Solà C, Estivill X, Menchón JM. Alonso P, et al. J Psychiatry Neurosci. 2012 Jul;37(4):273-81. doi: 10.1503/jpn.110109. J Psychiatry Neurosci. 2012. PMID: 22433450 Free PMC article.
BACKGROUND: Recent data from neuroimaging, genetic and clinical trials and animal models suggest a role for altered glutamatergic neuro transmission in the pathogenesis of obsessive-compulsive disorder (OCD). The aim of this study was to investigate whether variants in the …
BACKGROUND: Recent data from neuroimaging, genetic and clinical trials and animal models suggest a role for altered glutamatergic neuro tran …
Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study.
Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Arnold PD, et al. Psychopharmacology (Berl). 2004 Aug;174(4):530-8. doi: 10.1007/s00213-004-1847-1. Epub 2004 Apr 9. Psychopharmacology (Berl). 2004. PMID: 15083261
RATIONALE: Recent investigation suggests that a reversible glutamatergically mediated thalamocortical-striatal dysfunction may serve as a reliable pathophysiological and treatment response marker for obsessive-compulsive disorder (OCD). We postulated that N-methyl- d-aspar …
RATIONALE: Recent investigation suggests that a reversible glutamatergically mediated thalamocortical-striatal dysfunction may serve as a re …
Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives.
Karthik S, Sharma LP, Narayanaswamy JC. Karthik S, et al. Neuropsychiatr Dis Treat. 2020 Apr 17;16:1003-1013. doi: 10.2147/NDT.S211703. eCollection 2020. Neuropsychiatr Dis Treat. 2020. PMID: 32368062 Free PMC article. Review.
Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS) functions, including excitotoxicity and neuronal migration. ...In this review, we attempt to elucidate the role of glutamate in …
Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (C …
New horizons for obsessive-compulsive disorder drug discovery: is targeting glutamate receptors the answer?
Grassi G, Scillitani E, Cecchelli C. Grassi G, et al. Expert Opin Drug Discov. 2024 Oct;19(10):1235-1245. doi: 10.1080/17460441.2024.2387127. Epub 2024 Aug 6. Expert Opin Drug Discov. 2024. PMID: 39105546 Review.
INTRODUCTION: Over the past decade, glutamate has emerged as a prominent focus in the field of obsessive-compulsive disorder (OCD) pathophysiology. ...In light of these findings, there has been a growing interest in exploring the potential of glutamatergic agents in …
INTRODUCTION: Over the past decade, glutamate has emerged as a prominent focus in the field of obsessive-compulsive disorder (OCD …
Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept.
Rodriguez CI, Kegeles LS, Levinson A, Feng T, Marcus SM, Vermes D, Flood P, Simpson HB. Rodriguez CI, et al. Neuropsychopharmacology. 2013 Nov;38(12):2475-83. doi: 10.1038/npp.2013.150. Epub 2013 Jun 19. Neuropsychopharmacology. 2013. PMID: 23783065 Free PMC article. Clinical Trial.
As converging evidence suggests a role for the glutamate system in the pathophysiology of OCD, we tested whether a single dose of ketamine, a non-competitive N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, could achieve rapid anti-obsessiona …
As converging evidence suggests a role for the glutamate system in the pathophysiology of OCD, we tested whether a single dose …
Glutamatergic agents for OCD and related disorders.
Pittenger C. Pittenger C. Curr Treat Options Psychiatry. 2015 Sep;2(3):271-283. doi: 10.1007/s40501-015-0051-8. Curr Treat Options Psychiatry. 2015. PMID: 26301176 Free PMC article.
While no glutamate modulator can be considered proven as an efficacious treatment of OCD, promising suggestions of benefit have been reported for memantine and riluzole. ...It is notable that these agents all work by different, and in some cases opposite, mechanisms …
While no glutamate modulator can be considered proven as an efficacious treatment of OCD, promising suggestions of benefit hav …
Effects of glutamate-related drugs on anxiety and compulsive behavior in rats with obsessive-compulsive disorder.
Zhan Y, Xia J, Wang X. Zhan Y, et al. Int J Neurosci. 2020 Jun;130(6):551-560. doi: 10.1080/00207454.2019.1684276. Epub 2019 Dec 11. Int J Neurosci. 2020. PMID: 31680595
Objective: Altered glutamatergic neurotransmission has been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). We examined the effects and potential mechanism of glutamate-related drugs on compulsive behavior in quinpirole (QNP)-sensitized rats, …
Objective: Altered glutamatergic neurotransmission has been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). We …
Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.
Cioffi CL, Guzzo PR. Cioffi CL, et al. Curr Top Med Chem. 2016;16(29):3404-3437. doi: 10.2174/1568026616666160405113340. Curr Top Med Chem. 2016. PMID: 27048272 Review.
Glycine acts as an inhibitory neurotransmitter at glycine receptor (GlyR)-enriched synapses and as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptor, where it facilitates neuronal excitation. Two high-affinity and substrate selective transporters, glycin …
Glycine acts as an inhibitory neurotransmitter at glycine receptor (GlyR)-enriched synapses and as an obligatory co-agonist at the N-methyl- …
An attractor hypothesis of obsessive-compulsive disorder.
Rolls ET, Loh M, Deco G. Rolls ET, et al. Eur J Neurosci. 2008 Aug;28(4):782-93. doi: 10.1111/j.1460-9568.2008.06379.x. Epub 2008 Jul 30. Eur J Neurosci. 2008. PMID: 18671737
In integrate-and-fire network simulations, an increase in the N-methyl-d-aspartate (NMDA) and/or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor conductances, which increases the depth of the attractor basins, increases the stability of attr …
In integrate-and-fire network simulations, an increase in the N-methyl-d-aspartate (NMDA) and/or alpha-amino-3-hydroxy-5-methyl-4-iso …
Glutamatergic Agents as Add-On Medication for the Treatment of Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis.
Laoutidis ZG, Lekka GE, Kioulos KT. Laoutidis ZG, et al. J Clin Psychiatry. 2016 Dec;77(12):e1576-e1583. doi: 10.4088/JCP.15r10164. J Clin Psychiatry. 2016. PMID: 27780337
OBJECTIVE: The aim of the present study was to review the existing literature on clinical trials with glutamatergic agents in adults with obsessive-compulsive disorder (OCD) and to perform a meta-analysis to estimate the overall effect size. DATA SOURCES: We searched in ME …
OBJECTIVE: The aim of the present study was to review the existing literature on clinical trials with glutamatergic agents in adults with ob …
25 results