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Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.
Conforto TL, Steinhardt GF 4th, Waxman DJ. Conforto TL, et al. Mol Endocrinol. 2015 Sep;29(9):1286-302. doi: 10.1210/me.2015-1028. Epub 2015 Jul 28. Mol Endocrinol. 2015. PMID: 26218442 Free PMC article.
Hepatocyte-enriched nuclear factor (HNF)6 and CUX2 are GH and STAT5-regulated homeobox transcription factors. CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas …
Hepatocyte-enriched nuclear factor (HNF)6 and CUX2 are GH and STAT5-regulated homeobox transcription factors. CUX2 shows female-specific exp …
Neonatal xenoestrogen exposure alters growth hormone-dependent liver proteins and genes in adult female rats.
Ramirez MC, Bourguignon NS, Bonaventura MM, Lux-Lantos V, Libertun C, Becu-Villalobos D. Ramirez MC, et al. Toxicol Lett. 2012 Sep 18;213(3):325-31. doi: 10.1016/j.toxlet.2012.07.015. Epub 2012 Jul 25. Toxicol Lett. 2012. PMID: 22842222
The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. ...Liver Cyp2c11, Cyp2c12, Adh1, Hnf6, and Prlr mRNA levels were determined by real time PCR. ...
The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. ...Liver Cy …
Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver.
Delesque-Touchard N, Park SH, Waxman DJ. Delesque-Touchard N, et al. J Biol Chem. 2000 Nov 3;275(44):34173-82. doi: 10.1074/jbc.M004027200. J Biol Chem. 2000. PMID: 10931833 Free article.
CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose expression is activated by continuous GH stimulation of hepatocytes. Presently, we investigated the role of liver-enriched and GH-regulated transcription factors in the activation of CYP2C12 …
CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose expression is activated by continuous GH stimulation of he …
Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.
Briançon N, Bailly A, Clotman F, Jacquemin P, Lemaigre FP, Weiss MC. Briançon N, et al. J Biol Chem. 2004 Aug 6;279(32):33398-408. doi: 10.1074/jbc.M405312200. Epub 2004 May 24. J Biol Chem. 2004. PMID: 15159395 Free article.
The hepatocyte nuclear factor (HNF) 4alpha gene possesses two promoters, proximal P1 and distal P2, whose use results in HNF4alpha1 and HNF4alpha7 transcripts, respectively. Both isoforms are expressed in the embryonic liver, whereas HNF4alpha1 is almost exclusively in the …
The hepatocyte nuclear factor (HNF) 4alpha gene possesses two promoters, proximal P1 and distal P2, whose use results in HNF4alpha1 and HNF4 …
Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation.
Ding X, Yang Y, Han B, Du C, Xu N, Huang H, Cai T, Zhang A, Han ZG, Zhou W, Chen L. Ding X, et al. PLoS One. 2014 May 5;9(5):e95307. doi: 10.1371/journal.pone.0095307. eCollection 2014. PLoS One. 2014. PMID: 24798046 Free PMC article. Clinical Trial.
The transcriptomes of the CTNNB1 mutation-positive HCC samples from the HBV-positive patients (CB+ HCC) were compared to adjacent non-cancerous livers, and significantly altered genes were functionally validated in vitro. ...A distinct pattern of CTNNB1 mutation was detect …
The transcriptomes of the CTNNB1 mutation-positive HCC samples from the HBV-positive patients (CB+ HCC) were compared to adjacent non-cancer …
Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.
Wang K, Wang M, Gannon M, Holterman A. Wang K, et al. PLoS One. 2016 Dec 9;11(12):e0167085. doi: 10.1371/journal.pone.0167085. eCollection 2016. PLoS One. 2016. PMID: 27936029 Free PMC article.
In vitro, primary hepatocytes derived from KO and WT liver were treated with LPS and hepatocyte apoptosis was assessed with and without GH treatment. ...Ciap1 expression patterns closely follow Hnf6 expression in the liver and in hepatocytes. CONCLUSION: GH broad pr …
In vitro, primary hepatocytes derived from KO and WT liver were treated with LPS and hepatocyte apoptosis was assessed with and witho …
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells.
Inada H, Udono M, Matsuda-Ito K, Horisawa K, Ohkawa Y, Miura S, Goya T, Yamamoto J, Nagasaki M, Ueno K, Saitou D, Suyama M, Maehara Y, Kumamaru W, Ogawa Y, Sekiya S, Suzuki A. Inada H, et al. Nat Commun. 2020 Oct 21;11(1):5292. doi: 10.1038/s41467-020-19041-z. Nat Commun. 2020. PMID: 33087715 Free PMC article.
After transplantation, hiHepPC-derived hepatocytes and cholangiocytes reconstitute damaged liver tissues and support hepatic function. The defined transcription factors also induce hiHepPCs from endothelial cells circulating in adult human peripheral blood. These ex …
After transplantation, hiHepPC-derived hepatocytes and cholangiocytes reconstitute damaged liver tissues and support hepatic function …
The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.
Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, Copeland NG, Costa RH. Rausa F, et al. Dev Biol. 1997 Dec 15;192(2):228-46. doi: 10.1006/dbio.1997.8744. Dev Biol. 1997. PMID: 9441664 Free article.
HNF-3 beta also mediates cell-specific transcription of genes important for the function of hepatocytes, intestinal and bronchiolar epithelial, and pancreatic acinar cells. We have previously identified a liver-enriched transcription factor, HNF-6, which is required for HN …
HNF-3 beta also mediates cell-specific transcription of genes important for the function of hepatocytes, intestinal and bronchiolar epitheli …
Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
Wiwi CA, Waxman DJ. Wiwi CA, et al. J Biol Chem. 2005 Feb 4;280(5):3259-68. doi: 10.1074/jbc.M409294200. Epub 2004 Nov 10. J Biol Chem. 2005. PMID: 15539409 Free article.
Cytochrome P450 2A2 (CYP2A2) is an adult male-specific rat liver steroid hydroxylase whose sex-dependent expression is regulated at the transcriptional level by sexually dimorphic pituitary growth hormone (GH) secretory patterns. In contrast to CYP2C11 and other mal …
Cytochrome P450 2A2 (CYP2A2) is an adult male-specific rat liver steroid hydroxylase whose sex-dependent expression is regulat …
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.
van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS. van Breda SGJ, et al. Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14. Toxicology. 2018. PMID: 29154799 Free article.
VPA treatment appeared to inhibit the expression of the transcription factors HNF1A and ONECUT1. HNF1A interacted with 41 differentially expressed genes of which 12 were also differentially methylated. None of the genes present in this network were regulated by a DE-miR. T …
VPA treatment appeared to inhibit the expression of the transcription factors HNF1A and ONECUT1. HNF1A interacted with 41 differentia …
18 results