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Year Number of Results
1997 1
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2000 3
2002 1
2003 1
2004 3
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2007 1
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2014 1
2015 1
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2017 1
2018 1
2020 0
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Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.
Conforto TL, Steinhardt GF 4th, Waxman DJ. Conforto TL, et al. Mol Endocrinol. 2015 Sep;29(9):1286-302. doi: 10.1210/me.2015-1028. Epub 2015 Jul 28. Mol Endocrinol. 2015. PMID: 26218442 Free PMC article.
CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels in male and female liver. ...HNF6 binding was sex independent at a …
CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many …
Neonatal xenoestrogen exposure alters growth hormone-dependent liver proteins and genes in adult female rats.
Ramirez MC, Bourguignon NS, Bonaventura MM, Lux-Lantos V, Libertun C, Becu-Villalobos D. Ramirez MC, et al. Toxicol Lett. 2012 Sep 18;213(3):325-31. doi: 10.1016/j.toxlet.2012.07.015. Epub 2012 Jul 25. Toxicol Lett. 2012. PMID: 22842222
The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. Preponderant sex differences are found in liver gene expression, mostly dependent on the sexually dimorphic pattern of GH secretion which is set during …
The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. Preponderant sex d …
Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver.
Delesque-Touchard N, Park SH, Waxman DJ. Delesque-Touchard N, et al. J Biol Chem. 2000 Nov 3;275(44):34173-82. doi: 10.1074/jbc.M004027200. J Biol Chem. 2000. PMID: 10931833 Free article.
CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose expression is activated by continuous GH stimulation of hepatocytes. Presently, we investigated the role of liver-enriched and GH-regulated transcription factors in the activation of CYP2C12 …
CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose expression is activated by continuous GH stimulation of he …
Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.
Briançon N, Bailly A, Clotman F, Jacquemin P, Lemaigre FP, Weiss MC. Briançon N, et al. J Biol Chem. 2004 Aug 6;279(32):33398-408. doi: 10.1074/jbc.M405312200. Epub 2004 May 24. J Biol Chem. 2004. PMID: 15159395 Free article.
Both isoforms are expressed in the embryonic liver, whereas HNF4alpha1 is almost exclusively in the adult liver. A 516-bp fragment, encompassing a DNase I-hypersensitive site associated with P2 activity that is still retained in adult liver, con …
Both isoforms are expressed in the embryonic liver, whereas HNF4alpha1 is almost exclusively in the adult liver. A 516- …
Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.
Wang K, Wang M, Gannon M, Holterman A. Wang K, et al. PLoS One. 2016 Dec 9;11(12):e0167085. doi: 10.1371/journal.pone.0167085. eCollection 2016. PLoS One. 2016. PMID: 27936029 Free PMC article.
GH was administered to adult wild type WT and KO mice for the 7 days of BDL to enhance Hnf6 expression. In vitro, primary hepatocytes derived from KO and WT liver were treated with LPS and hepatocyte apoptosis was assessed with and without GH treatment. ...Ciap1 exp …
GH was administered to adult wild type WT and KO mice for the 7 days of BDL to enhance Hnf6 expression. In vitro, primary hepatocytes …
Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation.
Ding X, Yang Y, Han B, Du C, Xu N, Huang H, Cai T, Zhang A, Han ZG, Zhou W, Chen L. Ding X, et al. PLoS One. 2014 May 5;9(5):e95307. doi: 10.1371/journal.pone.0095307. eCollection 2014. PLoS One. 2014. PMID: 24798046 Free PMC article. Clinical Trial.
A distinct pattern of CTNNB1 mutation was detected in these two populations, and drastic changes at the transcriptomic level were detected in the CB+ tumors compared to adjacent non-cancerous livers. ...Our work also suggests that targeting ONECUT1, FOXA3, SSX1, and …
A distinct pattern of CTNNB1 mutation was detected in these two populations, and drastic changes at the transcriptomic level were detected i …
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.
van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS. van Breda SGJ, et al. Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14. Toxicology. 2018. PMID: 29154799 Free article.
Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug probably by its HDAC inhibiting properties, which may cause steatosis in the liver. ...The subnetwork of ONECUT1 consisted of 44 differentially expressed genes of which 15 were differentially …
Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug probably by its HDAC inhibiting properties, which may cause steat …
The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.
Pierreux CE, Vanhorenbeeck V, Jacquemin P, Lemaigre FP, Rousseau GG. Pierreux CE, et al. J Biol Chem. 2004 Dec 3;279(49):51298-304. doi: 10.1074/jbc.M409038200. Epub 2004 Sep 20. J Biol Chem. 2004. PMID: 15381696 Free article.
These factors include the Onecut protein hepatocyte nuclear factor-6 (HNF-6), which controls pancreas and liver development as shown in our previous work on Hnf6 knock-out embryos. In mammals, HNF-6 has two paralogs, Onecut-2 (OC-2) and OC-3, whose patterns of expression i …
These factors include the Onecut protein hepatocyte nuclear factor-6 (HNF-6), which controls pancreas and liver development as shown …
The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.
Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, Copeland NG, Costa RH. Rausa F, et al. Dev Biol. 1997 Dec 15;192(2):228-46. doi: 10.1006/dbio.1997.8744. Dev Biol. 1997. PMID: 9441664 Free article.
More detailed analysis of HNF-6 and HNF-3 beta's developmental expression patterns provides evidence of colocalization in hepatocytes, intestinal epithelial, and in the pancreatic ductal epithelial and exocrine acinar cells. ...At day 18 of gestation and in the adult …
More detailed analysis of HNF-6 and HNF-3 beta's developmental expression patterns provides evidence of colocalization in hepatocytes …
Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
Wiwi CA, Waxman DJ. Wiwi CA, et al. J Biol Chem. 2005 Feb 4;280(5):3259-68. doi: 10.1074/jbc.M409294200. Epub 2004 Nov 10. J Biol Chem. 2005. PMID: 15539409 Free article.
Cytochrome P450 2A2 (CYP2A2) is an adult male-specific rat liver steroid hydroxylase whose sex-dependent expression is regulated at the transcriptional level by sexually dimorphic pituitary growth hormone (GH) secretory patterns. In contrast to CYP2C11 and other mal …
Cytochrome P450 2A2 (CYP2A2) is an adult male-specific rat liver steroid hydroxylase whose sex-dependent expression is regulat …
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