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Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography.
Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64. doi: 10.1016/j.neuropharm.2005.03.011. Neuropharmacology. 2005. PMID: 15993447
This study aimed to identify the effects of two novel ampakines, Org 26576 and Org 24448, on local cerebral glucose use (LCGU) in the mouse. C57BL/6J mice received Org 26576 (0.1, 1, 10 mg/kg i.p.) or Org 24448 (3, 10, 30 mg/kg i.p.) or vehicle and LCG …
This study aimed to identify the effects of two novel ampakines, Org 26576 and Org 24448, on local cerebral glucose use (LCGU) …
Carbonylative Transformations Using a DMAP-Based Pd-Catalyst through Ex Situ CO Generation.
Halder P, Iqubal A, Mondal K, Mukhopadhyay N, Das P. Halder P, et al. J Org Chem. 2023 Nov 3;88(21):15218-15236. doi: 10.1021/acs.joc.3c01725. Epub 2023 Oct 24. J Org Chem. 2023. PMID: 37874889
Various value-added pharmaceutically relevant compounds such as CX-516, CX-546, and farampator were synthesized using the technique. Furthermore, the commercially designed COware was engineered to COware-RB setup for sequential one-pot synthesis of indenoisoquinolines (top …
Various value-added pharmaceutically relevant compounds such as CX-516, CX-546, and farampator were synthesized using the technique. …
Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission.
Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH. Jardemark K, et al. Psychopharmacology (Berl). 2012 May;221(1):115-31. doi: 10.1007/s00213-011-2554-3. Epub 2011 Nov 9. Psychopharmacology (Berl). 2012. PMID: 22068461
RATIONALE: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor positive allosteric modulators (AMPA-PAMs), Org 24448 and Org 26576, and the glycine transporter-1 (GlyT-1) inhibitor Org 25935 are developed for treatment of schizophrenia. ... …
RATIONALE: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor positive allosteric modulators (AMPA-PAMs), Org …
Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?
Vale S. Vale S. Exp Biol Med (Maywood). 2008 Aug;233(8):941-51. doi: 10.3181/0707-MR-193. Epub 2008 Jun 5. Exp Biol Med (Maywood). 2008. PMID: 18535172 Review.
Preliminary studies with vehicles that may target PDpFCD include piribedil, tolcapone, amantadine, and farampator. Additional agents (citicoline and neuroimmuniphilines, among others) will be outlined. ...
Preliminary studies with vehicles that may target PDpFCD include piribedil, tolcapone, amantadine, and farampator. Additional agents …
Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers.
Wezenberg E, Verkes RJ, Ruigt GS, Hulstijn W, Sabbe BG. Wezenberg E, et al. Neuropsychopharmacology. 2007 Jun;32(6):1272-83. doi: 10.1038/sj.npp.1301257. Epub 2006 Nov 22. Neuropsychopharmacology. 2007. PMID: 17119538 Clinical Trial.
Ampakines act as positive allosteric modulators of AMPA-type glutamate receptors and facilitate hippocampal long-term potentiation (LTP), a mechanism associated with memory storage and consolidation. The present study investigated the acute effects of farampator, 1- …
Ampakines act as positive allosteric modulators of AMPA-type glutamate receptors and facilitate hippocampal long-term potentiation (LTP), a …
Novel analysis for improved validity in semi-quantitative 2-deoxyglucose autoradiographic imaging.
Dawson N, Ferrington L, Olverman HJ, Kelly PA. Dawson N, et al. J Neurosci Methods. 2008 Oct 30;175(1):25-35. doi: 10.1016/j.jneumeth.2008.07.020. Epub 2008 Aug 12. J Neurosci Methods. 2008. PMID: 18762213
Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by C-14-2-deoxyglucose autoradiography. ...
Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation …
Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.
Woolley ML, Waters KA, Gartlon JE, Lacroix LP, Jennings C, Shaughnessy F, Ong A, Pemberton DJ, Harries MH, Southam E, Jones DN, Dawson LA. Woolley ML, et al. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. doi: 10.1007/s00213-008-1325-2. Epub 2008 Sep 16. Psychopharmacology (Berl). 2009. PMID: 18795266