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Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.
Kalgutkar AS, Obach RS, Maurer TS. Kalgutkar AS, et al. Among authors: obach rs. Curr Drug Metab. 2007 Jun;8(5):407-47. doi: 10.2174/138920007780866807. Curr Drug Metab. 2007. PMID: 17584015 Review.
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP. Dalvie DK, et al. Among authors: obach rs. Chem Res Toxicol. 2002 Mar;15(3):269-99. doi: 10.1021/tx015574b. Chem Res Toxicol. 2002. PMID: 11896674 Review. No abstract available.
Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach.
Obach RS, Reed-Hagen AE. Obach RS, et al. Drug Metab Dispos. 2002 Jul;30(7):831-7. doi: 10.1124/dmd.30.7.831. Drug Metab Dispos. 2002. PMID: 12065442
Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors.
Tran TH, Von Moltke LL, Venkatakrishnan K, Granda BW, Gibbs MA, Obach RS, Harmatz JS, Greenblatt DJ. Tran TH, et al. Among authors: obach rs. Drug Metab Dispos. 2002 Dec;30(12):1441-5. doi: 10.1124/dmd.30.12.1441. Drug Metab Dispos. 2002. PMID: 12433817
Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine.
Bertelsen KM, Venkatakrishnan K, Von Moltke LL, Obach RS, Greenblatt DJ. Bertelsen KM, et al. Among authors: obach rs. Drug Metab Dispos. 2003 Mar;31(3):289-93. doi: 10.1124/dmd.31.3.289. Drug Metab Dispos. 2003. PMID: 12584155
Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions.
Margolis JM, Obach RS. Margolis JM, et al. Among authors: obach rs. Drug Metab Dispos. 2003 May;31(5):606-11. doi: 10.1124/dmd.31.5.606. Drug Metab Dispos. 2003. PMID: 12695349
The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective.
Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach RS, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J, Wrighton SA; Pharmaceutical Research and Manufacturers of America (PhRMA) Drug Metabolism/Clinical Pharmacology Technical Working Group; FDA Center for Drug Evaluation and Research (CDER). Bjornsson TD, et al. Among authors: obach rs. Drug Metab Dispos. 2003 Jul;31(7):815-32. doi: 10.1124/dmd.31.7.815. Drug Metab Dispos. 2003. PMID: 12814957
Drug-drug interactions: an important negative attribute in drugs.
Obach RS. Obach RS. Drugs Today (Barc). 2003 May;39(5):301-38. doi: 10.1358/dot.2003.39.5.799456. Drugs Today (Barc). 2003. PMID: 12861346 Review.
Drug metabolism and drug interactions: application and clinical value of in vitro models.
Venkatakrishnan K, von Moltke LL, Obach RS, Greenblatt DJ. Venkatakrishnan K, et al. Among authors: obach rs. Curr Drug Metab. 2003 Oct;4(5):423-59. doi: 10.2174/1389200033489361. Curr Drug Metab. 2003. PMID: 14529374 Review.
Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.
O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. O'Donnell JP, et al. Among authors: obach rs. Drug Metab Dispos. 2003 Nov;31(11):1369-77. doi: 10.1124/dmd.31.11.1369. Drug Metab Dispos. 2003. PMID: 14570769
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