Obach RS - Search Results

1

Addressing the challenges of low clearance in drug research.

Di L, Obach RS. Di L, et al. Among authors: obach rs. AAPS J. 2015 Mar;17(2):352-7. doi: 10.1208/s12248-014-9691-7. Epub 2015 Jan 8. AAPS J. 2015. PMID: 25567366 Free PMC article. Review.

2

Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.

Lombardo F, Obach RS, Shalaeva MY, Gao F. Lombardo F, et al. Among authors: obach rs. J Med Chem. 2002 Jun 20;45(13):2867-76. doi: 10.1021/jm0200409. J Med Chem. 2002. PMID: 12061889

3

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach.

Obach RS, Reed-Hagen AE. Obach RS, et al. Drug Metab Dispos. 2002 Jul;30(7):831-7. doi: 10.1124/dmd.30.7.831. Drug Metab Dispos. 2002. PMID: 12065442

4

Drug-drug interactions: an important negative attribute in drugs.

Obach RS. Obach RS. Drugs Today (Barc). 2003 May;39(5):301-38. doi: 10.1358/dot.2003.39.5.799456. Drugs Today (Barc). 2003. PMID: 12861346 Review.

5

Drug metabolism and drug interactions: application and clinical value of in vitro models.

Venkatakrishnan K, von Moltke LL, Obach RS, Greenblatt DJ. Venkatakrishnan K, et al. Among authors: obach rs. Curr Drug Metab. 2003 Oct;4(5):423-59. doi: 10.2174/1389200033489361. Curr Drug Metab. 2003. PMID: 14529374 Review.

6

Reaction phenotyping in drug discovery: moving forward with confidence?

Williams JA, Hurst SI, Bauman J, Jones BC, Hyland R, Gibbs JP, Obach RS, Ball SE. Williams JA, et al. Among authors: obach rs. Curr Drug Metab. 2003 Dec;4(6):527-34. doi: 10.2174/1389200033489235. Curr Drug Metab. 2003. PMID: 14683480 Review.

7

Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.

Lombardo F, Obach RS, Shalaeva MY, Gao F. Lombardo F, et al. Among authors: obach rs. J Med Chem. 2004 Feb 26;47(5):1242-50. doi: 10.1021/jm030408h. J Med Chem. 2004. PMID: 14971904

8

Validated assays for human cytochrome P450 activities.

Walsky RL, Obach RS. Walsky RL, et al. Among authors: obach rs. Drug Metab Dispos. 2004 Jun;32(6):647-60. doi: 10.1124/dmd.32.6.647. Drug Metab Dispos. 2004. PMID: 15155557

9

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Among authors: obach rs. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

10

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing.

Smith DA, Obach RS. Smith DA, et al. Among authors: obach rs. Drug Metab Dispos. 2005 Oct;33(10):1409-17. doi: 10.1124/dmd.105.005041. Epub 2005 Jun 28. Drug Metab Dispos. 2005. PMID: 15985503

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