Obach RS - Search Results

1

The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations.

Obach RS. Obach RS. Drug Metab Dispos. 1996 Oct;24(10):1047-9. Drug Metab Dispos. 1996. PMID: 8894503 No abstract available.

2

In vitro metabolism of irosustat, a novel steroid sulfatase inhibitor: interspecies comparison, metabolite identification, and metabolic enzyme identification.

Ventura V, Solà J, Celma C, Peraire C, Obach R. Ventura V, et al. Drug Metab Dispos. 2011 Jul;39(7):1235-46. doi: 10.1124/dmd.111.038315. Epub 2011 Apr 4. Drug Metab Dispos. 2011. PMID: 21464173

3

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

Obach RS. Obach RS. Drug Metab Dispos. 1997 Dec;25(12):1359-69. Drug Metab Dispos. 1997. PMID: 9394025

4

Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.

Obach RS. Obach RS. Drug Metab Dispos. 2000 Sep;28(9):1069-76. Drug Metab Dispos. 2000. PMID: 10950851

5

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

Obach RS. Obach RS. Drug Metab Dispos. 1999 Nov;27(11):1350-9. Drug Metab Dispos. 1999. PMID: 10534321

6

Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction.

Obach RS. Obach RS. Drug Metab Dispos. 2001 Jul;29(7):1057-67. Drug Metab Dispos. 2001. PMID: 11408374

7

Oral idazoxan bioavailability in rat. Relevance of intestinal and hepatic first-pass effect.

Vallès J, Pruñonosa J, Menargues A, Nomen M, Obach R. Vallès J, et al. Drug Metab Dispos. 1989 Nov-Dec;17(6):673-6. Drug Metab Dispos. 1989. PMID: 2575506

8

Radioimmunoassay of nicotine-delta 1'(5')-iminium ion, an intermediate formed during the metabolism of nicotine to cotinine.

Obach RS, van Vunakis H. Obach RS, et al. Drug Metab Dispos. 1990 Jul-Aug;18(4):508-13. Drug Metab Dispos. 1990. PMID: 1976076

9

In vitro evaluation of the interaction potential of irosustat with drug-metabolizing enzymes.

Ventura V, Solà J, Peraire C, Brée F, Obach R. Ventura V, et al. Drug Metab Dispos. 2012 Jul;40(7):1268-78. doi: 10.1124/dmd.111.044271. Epub 2012 Mar 26. Drug Metab Dispos. 2012. PMID: 22451700

10

Pharmacokinetics and oral bioavailability of carbimide in man.

Obach R, Torrent J, Colom H, Pruñonosa J, Peraire C, Domenech J. Obach R, et al. Biopharm Drug Dispos. 1991 Aug-Sep;12(6):425-34. doi: 10.1002/bdd.2510120604. Biopharm Drug Dispos. 1991. PMID: 1932606 Clinical Trial.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

Search Page

Search Results