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Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.
Paine MF, Oberlies NH. Paine MF, et al. Among authors: oberlies nh. Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):67-80. doi: 10.1517/17425255.3.1.67. Expert Opin Drug Metab Toxicol. 2007. PMID: 17269895 Review.
Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.
Ngo N, Yan Z, Graf TN, Carrizosa DR, Kashuba AD, Dees EC, Oberlies NH, Paine MF. Ngo N, et al. Among authors: oberlies nh. Drug Metab Dispos. 2009 Mar;37(3):514-22. doi: 10.1124/dmd.108.024968. Epub 2008 Dec 29. Drug Metab Dispos. 2009. PMID: 19114462 Free PMC article.
The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation.
Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF. Ngo N, et al. Among authors: oberlies nh. J Exp Pharmacol. 2010 Jul;2010(2):83-91. doi: 10.2147/JEP.S11719. J Exp Pharmacol. 2010. PMID: 20865058 Free PMC article.
Influence of dietary substances on intestinal drug metabolism and transport.
Won CS, Oberlies NH, Paine MF. Won CS, et al. Among authors: oberlies nh. Curr Drug Metab. 2010 Nov;11(9):778-92. doi: 10.2174/138920010794328869. Curr Drug Metab. 2010. PMID: 21189136 Free PMC article. Review.
Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.
Won CS, Oberlies NH, Paine MF. Won CS, et al. Among authors: oberlies nh. Pharmacol Ther. 2012 Nov;136(2):186-201. doi: 10.1016/j.pharmthera.2012.08.001. Epub 2012 Aug 4. Pharmacol Ther. 2012. PMID: 22884524 Free PMC article. Review.
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Köck K, Xie Y, Hawke RL, Oberlies NH, Brouwer KL. Köck K, et al. Among authors: oberlies nh. Drug Metab Dispos. 2013 May;41(5):958-65. doi: 10.1124/dmd.112.048272. Epub 2013 Feb 11. Drug Metab Dispos. 2013. PMID: 23401473 Free PMC article.
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Althagafy HS, Graf TN, Sy-Cordero AA, Gufford BT, Paine MF, Wagoner J, Polyak SJ, Croatt MP, Oberlies NH. Althagafy HS, et al. Among authors: oberlies nh. Bioorg Med Chem. 2013 Jul 1;21(13):3919-26. doi: 10.1016/j.bmc.2013.04.017. Epub 2013 Apr 16. Bioorg Med Chem. 2013. PMID: 23673225 Free PMC article.
Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography.
Vandermolen KM, Cech NB, Paine MF, Oberlies NH. Vandermolen KM, et al. Among authors: oberlies nh. Phytochem Anal. 2013 Nov-Dec;24(6):654-60. doi: 10.1002/pca.2449. Epub 2013 Jun 18. Phytochem Anal. 2013. PMID: 23780830 Free PMC article.
A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.
Brantley SJ, Graf TN, Oberlies NH, Paine MF. Brantley SJ, et al. Among authors: oberlies nh. Drug Metab Dispos. 2013 Sep;41(9):1662-70. doi: 10.1124/dmd.113.052563. Epub 2013 Jun 25. Drug Metab Dispos. 2013. PMID: 23801821 Free PMC article.
A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo "connect".
Won CS, Lan T, Vandermolen KM, Dawson PA, Oberlies NH, Widmer WW, Scarlett YV, Paine MF. Won CS, et al. Among authors: oberlies nh. J Clin Pharmacol. 2013 Sep;53(9):982-90. doi: 10.1002/jcph.136. Epub 2013 Jul 23. J Clin Pharmacol. 2013. PMID: 23878024 Free PMC article. Clinical Trial.
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