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Page 1
Ecotoxicological potential of the biocides terbutryn, octhilinone and methylisothiazolinone: Underestimated risk from biocidal pathways?
Kresmann S, Arokia AHR, Koch C, Sures B. Kresmann S, et al. Sci Total Environ. 2018 Jun 1;625:900-908. doi: 10.1016/j.scitotenv.2017.12.280. Epub 2018 Jan 5. Sci Total Environ. 2018. PMID: 29306832
Further, the MTT assay with the ovarian cell line CHO-9 from Chinese hamster was used as mammalian model. Octhilinone induced the strongest effects with EC(50) values of 156mug/l in the D. magna assay, while terbutryn showed the weakest effects with 8390mug/l and methyliso …
Further, the MTT assay with the ovarian cell line CHO-9 from Chinese hamster was used as mammalian model. Octhilinone induced the str …
Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.
Matuszak N, Es Saadi B, Labar G, Marchand-Brynaert J, Lambert DM. Matuszak N, et al. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7321-4. doi: 10.1016/j.bmcl.2011.10.026. Epub 2011 Oct 18. Bioorg Med Chem Lett. 2011. PMID: 22056744
Here, we further investigate the mechanism by which octhilinone and its benzisothiazolinone analog inhibit human MAGL. We also provide new information on the structural requirements for MAGL inhibition by these compounds. Finally, we describe for N-octylbenzisothiazolinone …
Here, we further investigate the mechanism by which octhilinone and its benzisothiazolinone analog inhibit human MAGL. We also provid …
A strategy for an initial assessment of the ecotoxicological effects of transformation products of pesticides in aquatic systems following a tiered approach.
Hensen B, Olsson O, Kümmerer K. Hensen B, et al. Environ Int. 2020 Apr;137:105533. doi: 10.1016/j.envint.2020.105533. Epub 2020 Feb 26. Environ Int. 2020. PMID: 32113087 Free article. Review.
The six pesticides Boscalid, Penconazole, Diuron, Terbutryn, Octhilinone (OIT), and Mecoprop were used as model compounds. Identification of corresponding environmental known and unknown TPs were done by literature analysis and photolysis experiments in combination. ...
The six pesticides Boscalid, Penconazole, Diuron, Terbutryn, Octhilinone (OIT), and Mecoprop were used as model compounds. Identifica …
Risks of using antifouling biocides in aquaculture.
Guardiola FA, Cuesta A, Meseguer J, Esteban MA. Guardiola FA, et al. Int J Mol Sci. 2012;13(2):1541-1560. doi: 10.3390/ijms13021541. Epub 2012 Feb 2. Int J Mol Sci. 2012. PMID: 22408407 Free PMC article. Review.
The biocides that are most commonly used in antifouling paints include chlorothalonil, dichlofluanid, DCOIT (4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, Sea-nine 211()), Diuron, Irgarol 1051, TCMS pyridine (2,3,3,6-tetrachloro-4-m …
The biocides that are most commonly used in antifouling paints include chlorothalonil, dichlofluanid, DCOIT (4,5-dichloro-2-n- …
Rolling--a new application technique for luminescent bacteria on high-performance thin-layer chromatography plates.
Baumgartner V, Hohl C, Schwack W. Baumgartner V, et al. J Chromatogr A. 2011 May 13;1218(19):2692-9. doi: 10.1016/j.chroma.2011.01.039. Epub 2011 Jan 31. J Chromatogr A. 2011. PMID: 21329931
The rolling device was made of commercially available household articles. Using octhilinone and methylparaben as test compounds, rolling was compared with dipping. Despite of performing the rolling process manually, the results were reproducible. ...
The rolling device was made of commercially available household articles. Using octhilinone and methylparaben as test compounds, roll …
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors.
King AR, Lodola A, Carmi C, Fu J, Mor M, Piomelli D. King AR, et al. Br J Pharmacol. 2009 Jul;157(6):974-83. doi: 10.1111/j.1476-5381.2009.00276.x. Epub 2009 May 26. Br J Pharmacol. 2009. PMID: 19486005 Free PMC article.
KEY RESULTS: The screening revealed that 2-octyl-4-isothiazolin-3-one (octhilinone) inhibited purified rat recombinant MGL (IC(50)= 88 +/- 12 nM) through a partially reversible mechanism. ...The inhibitory potency of octhilinone was selectively decreased by mutating …
KEY RESULTS: The screening revealed that 2-octyl-4-isothiazolin-3-one (octhilinone) inhibited purified rat recombinant MGL (IC(50)= 8 …
A Commonly Used Biocide 2-N-octyl-4-isothiazolin-3-oneInduces Blood-Brain Barrier Dysfunction via Cellular Thiol Modification and Mitochondrial Damage.
Kim D, Kim EH, Choi S, Lim KM, Tie L, Majid A, Bae ON. Kim D, et al. Int J Mol Sci. 2021 Mar 4;22(5):2563. doi: 10.3390/ijms22052563. Int J Mol Sci. 2021. PMID: 33806369 Free PMC article.
Isothiazolinone (IT) biocides are potent antibacterial substances commonly used as preservatives or disinfectants, and 2-n-Octyl-4-isothiazolin-3-one (OIT; octhilinone) is a common IT biocide that is present in leather produ …
Isothiazolinone (IT) biocides are potent antibacterial substances commonly used as preservatives or disinfectants, and 2-n- …
Biocide patch tests.
Andersen KE, Veien NK. Andersen KE, et al. Contact Dermatitis. 1985 Feb;12(2):99-103. doi: 10.1111/j.1600-0536.1985.tb01061.x. Contact Dermatitis. 1985. PMID: 3157538
Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMK), 2-n-octyl-4-isothiazolin-3-one (Kathon 893), polyhydroxymet …
Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522), benzisothiazolin-3-one (BIT) …
Transcriptomics integrated with metabolomics reveal the competitive relationship between co-cultured Trichoderma asperellum HG1 and Bacillus subtilis Tpb55.
Li Q, Lin W, Zhang X, Wang M, Zheng Y, Wang X, Gao G, Li Y, Zhao D, Zhang C. Li Q, et al. Microbiol Res. 2024 Mar;280:127598. doi: 10.1016/j.micres.2023.127598. Epub 2024 Jan 2. Microbiol Res. 2024. PMID: 38176360
In addition, co-culture also accelerated the production of intracellular anti-oomycete compound octhilinone. The above results indicate that HG1 and Tpb55 are mainly in a competitive relationship in the co culture system. ...
In addition, co-culture also accelerated the production of intracellular anti-oomycete compound octhilinone. The above results indica …
76 results