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Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.
Yamamoto S, Ooshima Y, Nakata M, Yano T, Matsuoka K, Watanabe S, Maeda R, Takahashi H, Takeyama M, Matsumoto Y, Hashimoto T. Yamamoto S, et al. Transgenic Res. 2013 Jun;22(3):537-47. doi: 10.1007/s11248-012-9651-x. Epub 2012 Sep 9. Transgenic Res. 2013. PMID: 22961199
Here, we report the establishment and characterization of novel ES cell lines from a mouse model of Alzheimer's disease (3xTg-AD mouse, Oddo et al. in Neuron 39:409-421, 2003) harboring 3 mutated genes (APPswe, TauP301L, and PS1M146V) and a comp …
Here, we report the establishment and characterization of novel ES cell lines from a mouse model of Alzheimer's disease (3xTg-AD mouse, O …