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Guidance for the adjustment of FRAX according to the dose of glucocorticoids.
Kanis JA, Johansson H, Oden A, McCloskey EV. Kanis JA, et al. Among authors: oden a. Osteoporos Int. 2011 Mar;22(3):809-16. doi: 10.1007/s00198-010-1524-7. Epub 2011 Jan 13. Osteoporos Int. 2011. PMID: 21229233
We examined the effect of glucocorticoid dose on FRAX® derived fracture probabilities in a UK setting. A relatively simple adjustment of conventional FRAX estimates of probabilities of hip fracture and a major osteoporotic fracture can be applied to modulate …
We examined the effect of glucocorticoid dose on FRAX® derived fracture probabilities in a UK setting. A relatively simple adj …
Uncertain future of trials in osteoporosis.
Kanis JA, Oden A, Johnell O, Caulin F, Bone H, Alexandre JM, Abadie E, Lekkerkerker F. Kanis JA, et al. Among authors: oden a. Osteoporos Int. 2002;13(6):443-9. doi: 10.1007/s001980200052. Osteoporos Int. 2002. PMID: 12107656 Review.
In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves....
In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A mo …
Inflammatory bowel disease and the risk of fracture after controlling for FRAX.
Targownik LE, Bernstein CN, Nugent Z, Johansson H, Oden A, McCloskey E, Kanis JA, Leslie WD. Targownik LE, et al. Among authors: oden a. J Bone Miner Res. 2013 May;28(5):1007-13. doi: 10.1002/jbmr.1848. J Bone Miner Res. 2013. PMID: 23239264
A population-based database containing clinical information on all IBD subjects in the province of Manitoba, Canada, was linked with the Manitoba Bone Mineral Density Database, which contains results of all dual X-ray absorptiometry (DXA) scans in the province. ...The addi
A population-based database containing clinical information on all IBD subjects in the province of Manitoba, Canada, was linked with
FRAX underestimates fracture risk in patients with diabetes.
Giangregorio LM, Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA. Giangregorio LM, et al. Among authors: oden a. J Bone Miner Res. 2012 Feb;27(2):301-8. doi: 10.1002/jbmr.556. J Bone Miner Res. 2012. PMID: 22052532
The study objective was to determine whether diabetes is a risk factor for incident hip or major osteoporotic fractures independent of the WHO fracture risk assessment tool (FRAX). ...FRAX probabilities were calculated, and fracture outcomes to 2008 were established via li …
The study objective was to determine whether diabetes is a risk factor for incident hip or major osteoporotic fractures independent o …
Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration.
Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA; Manitoba Bone Density Program. Leslie WD, et al. Among authors: oden a. J Bone Miner Res. 2010 Nov;25(11):2350-8. doi: 10.1002/jbmr.123. J Bone Miner Res. 2010. PMID: 20499367
The 10-year estimate of osteoporotic fracture risk for all women was 12.0% (95% CI 10.8-13.4%) with a predicted value of 11.1% for FRAX with BMD, and in men, the observed risk was 10.7% (95% CI 6.6-14.9%) with a predicted value of 8.4%. ...In conclusion, a Ca …
The 10-year estimate of osteoporotic fracture risk for all women was 12.0% (95% CI 10.8-13.4%) with a predicted value of 11.1% for FR …
The impact of the use of multiple risk indicators for fracture on case-finding strategies: a mathematical approach.
De Laet C, Odén A, Johansson H, Johnell O, Jönsson B, Kanis JA. De Laet C, et al. Among authors: oden a. Osteoporos Int. 2005 Mar;16(3):313-8. doi: 10.1007/s00198-004-1689-z. Epub 2004 Jul 6. Osteoporos Int. 2005. PMID: 15241584
Fracture probability can be expressed as a risk gradient, i.e. a relative risk (RR) of fracture per standard deviation (SD) change in BMD. ...A risk indicator with a gradient of fracture risk of 2 per SD identified 36% of the population as having a
Fracture probability can be expressed as a risk gradient, i.e. a relative risk (RR) of fracture per standard deviation (SD) ch …
International variations in hip fracture probabilities: implications for risk assessment.
Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK. Kanis JA, et al. Among authors: oden a. J Bone Miner Res. 2002 Jul;17(7):1237-44. doi: 10.1359/jbmr.2002.17.7.1237. J Bone Miner Res. 2002. PMID: 12096837
It is recommended that intervention thresholds should be based on absolute fracture risk, but there is a large variation in hip fracture incidence from different regions of the world. ...The categorization of hip fracture probabilities can be used to adjust intervention th …
It is recommended that intervention thresholds should be based on absolute fracture risk, but there is a large variation in hip fract …
Excess mortality after hospitalisation for vertebral fracture.
Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B. Kanis JA, et al. Among authors: oden a. Osteoporos Int. 2004 Feb;15(2):108-12. doi: 10.1007/s00198-003-1516-y. Epub 2003 Nov 4. Osteoporos Int. 2004. PMID: 14598026
After a short period of declining risk, the risk increased with age at a rate that was higher than that of the general population and comparable to that 1 year after hip fracture. ...We conclude that a minority of deaths following hospitalization for vertebra …
After a short period of declining risk, the risk increased with age at a rate that was higher than that of the general populat …
Evaluation of the FRAX model for hip fracture predictions in the population-based Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE).
Sund R, Honkanen R, Johansson H, Odén A, McCloskey E, Kanis J, Kröger H. Sund R, et al. Among authors: oden a. Calcif Tissue Int. 2014 Jul;95(1):39-45. doi: 10.1007/s00223-014-9860-9. Epub 2014 May 4. Calcif Tissue Int. 2014. PMID: 24792689
Calibration of the Finnish FRAX model was evaluated using a locally derived population-based cohort of postmenopausal women (n = 13,917). ...Self-reports missed to capture 38 % of all hip fractures in those who responded and about 45 % of hip fractures in women who had …
Calibration of the Finnish FRAX model was evaluated using a locally derived population-based cohort of postmenopausal women (n = 13,9 …
Does osteoporosis therapy invalidate FRAX for fracture prediction?
Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA; Manitoba Bone Density Program. Leslie WD, et al. Among authors: oden a. J Bone Miner Res. 2012 Jun;27(6):1243-51. doi: 10.1002/jbmr.1582. J Bone Miner Res. 2012. PMID: 22392538
A total of 35,764 women (age ≥50 years) and baseline BMD testing (1996–2007) had FRAX probabilities retroactively calculated. ...In untreated and each treated subgroup, a stepwise gradient in observed 10-year major osteoporotic and hip fracture incidence was found a
A total of 35,764 women (age ≥50 years) and baseline BMD testing (1996–2007) had FRAX probabilities retroactively calculated. ...In u
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