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GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors.
Ahmed K, Tunaru S, Offermanns S. Ahmed K, et al. Among authors: offermanns s. Trends Pharmacol Sci. 2009 Nov;30(11):557-62. doi: 10.1016/ Trends Pharmacol Sci. 2009. PMID: 19837462
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. Tunaru S, et al. Among authors: offermanns s. Nat Med. 2003 Mar;9(3):352-5. doi: 10.1038/nm824. Epub 2003 Feb 3. Nat Med. 2003. PMID: 12563315
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.
Vogt S, Grosse R, Schultz G, Offermanns S. Vogt S, et al. Among authors: offermanns s. J Biol Chem. 2003 Aug 1;278(31):28743-9. doi: 10.1074/jbc.M304570200. Epub 2003 May 27. J Biol Chem. 2003. PMID: 12771155
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).
Tunaru S, Lättig J, Kero J, Krause G, Offermanns S. Tunaru S, et al. Among authors: offermanns s. Mol Pharmacol. 2005 Nov;68(5):1271-80. doi: 10.1124/mol.105.015750. Epub 2005 Aug 11. Mol Pharmacol. 2005. PMID: 16099840
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.
Benyó Z, Gille A, Kero J, Csiky M, Suchánková MC, Nüsing RM, Moers A, Pfeffer K, Offermanns S. Benyó Z, et al. Among authors: offermanns s. J Clin Invest. 2005 Dec;115(12):3634-40. doi: 10.1172/JCI23626. J Clin Invest. 2005. PMID: 16322797 Free PMC article.
The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target.
Offermanns S. Offermanns S. Trends Pharmacol Sci. 2006 Jul;27(7):384-90. doi: 10.1016/ Trends Pharmacol Sci. 2006. PMID: 16766048 Review.
Activation of platelet function through G protein-coupled receptors.
Offermanns S. Offermanns S. Circ Res. 2006 Dec 8;99(12):1293-304. doi: 10.1161/01.RES.0000251742.71301.16. Circ Res. 2006. PMID: 17158345 Review.
Conditional mutagenesis of G-protein coupled receptors and G-proteins.
Offermanns S. Offermanns S. Handb Exp Pharmacol. 2007;(178):491-509. doi: 10.1007/978-3-540-35109-2_20. Handb Exp Pharmacol. 2007. PMID: 17203668 Review.
Nicotinic acid: pharmacological effects and mechanisms of action.
Gille A, Bodor ET, Ahmed K, Offermanns S. Gille A, et al. Among authors: offermanns s. Annu Rev Pharmacol Toxicol. 2008;48:79-106. doi: 10.1146/annurev.pharmtox.48.113006.094746. Annu Rev Pharmacol Toxicol. 2008. PMID: 17705685 Review.
Nicotinic acid: an old drug with a promising future.
Bodor ET, Offermanns S. Bodor ET, et al. Among authors: offermanns s. Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S68-75. doi: 10.1038/sj.bjp.0707528. Epub 2007 Nov 26. Br J Pharmacol. 2008. PMID: 18037924 Free PMC article. Review.
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