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Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S. Tunaru S, et al. Among authors: offermanns s. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109. Epub 2012 May 21. Proc Natl Acad Sci U S A. 2012. PMID: 22615395 Free PMC article.
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.
Offermanns S, Laugwitz KL, Spicher K, Schultz G. Offermanns S, et al. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):504-8. doi: 10.1073/pnas.91.2.504. Proc Natl Acad Sci U S A. 1994. PMID: 8290554 Free PMC article.
The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.
Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G. Laugwitz KL, et al. Among authors: offermanns s. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):116-20. doi: 10.1073/pnas.93.1.116. Proc Natl Acad Sci U S A. 1996. PMID: 8552586 Free PMC article.
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. Tunaru S, et al. Among authors: offermanns s. Nat Med. 2003 Mar;9(3):352-5. doi: 10.1038/nm824. Epub 2003 Feb 3. Nat Med. 2003. PMID: 12563315
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.
Benyó Z, Gille A, Kero J, Csiky M, Suchánková MC, Nüsing RM, Moers A, Pfeffer K, Offermanns S. Benyó Z, et al. Among authors: offermanns s. J Clin Invest. 2005 Dec;115(12):3634-40. doi: 10.1172/JCI23626. J Clin Invest. 2005. PMID: 16322797 Free PMC article.
Nicotinic acid: pharmacological effects and mechanisms of action.
Gille A, Bodor ET, Ahmed K, Offermanns S. Gille A, et al. Among authors: offermanns s. Annu Rev Pharmacol Toxicol. 2008;48:79-106. doi: 10.1146/annurev.pharmtox.48.113006.094746. Annu Rev Pharmacol Toxicol. 2008. PMID: 17705685 Review.
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors.
Ahmed K, Tunaru S, Offermanns S. Ahmed K, et al. Among authors: offermanns s. Trends Pharmacol Sci. 2009 Nov;30(11):557-62. doi: 10.1016/j.tips.2009.09.001. Trends Pharmacol Sci. 2009. PMID: 19837462
An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.
Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. Ahmed K, et al. Among authors: offermanns s. Cell Metab. 2010 Apr 7;11(4):311-9. doi: 10.1016/j.cmet.2010.02.012. Cell Metab. 2010. PMID: 20374963
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. Hanson J, et al. Among authors: offermanns s. J Clin Invest. 2010 Aug;120(8):2910-9. doi: 10.1172/JCI42273. Epub 2010 Jul 26. J Clin Invest. 2010. PMID: 20664170 Free PMC article.
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.
Lukasova M, Malaval C, Gille A, Kero J, Offermanns S. Lukasova M, et al. Among authors: offermanns s. J Clin Invest. 2011 Mar;121(3):1163-73. doi: 10.1172/JCI41651. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317532 Free PMC article.
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