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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.
Oft M, Heider KH, Beug H. Oft M, et al. Curr Biol. 1998 Nov 19;8(23):1243-52. doi: 10.1016/s0960-9822(07)00533-7. Curr Biol. 1998. PMID: 9822576
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Oft M, Akhurst RJ, Balmain A. Oft M, et al. Nat Cell Biol. 2002 Jul;4(7):487-94. doi: 10.1038/ncb807. Nat Cell Biol. 2002. PMID: 12105419
Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.
Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. Lacher MD, et al. Among authors: oft m. Cancer Res. 2006 Feb 1;66(3):1648-57. doi: 10.1158/0008-5472.CAN-05-2328. Cancer Res. 2006. PMID: 16452224
The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.
Fialka I, Schwarz H, Reichmann E, Oft M, Busslinger M, Beug H. Fialka I, et al. Among authors: oft m. J Cell Biol. 1996 Mar;132(6):1115-32. doi: 10.1083/jcb.132.6.1115. J Cell Biol. 1996. PMID: 8601589 Free PMC article.
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Petritsch C, Beug H, Balmain A, Oft M. Petritsch C, et al. Among authors: oft m. Genes Dev. 2000 Dec 15;14(24):3093-101. doi: 10.1101/gad.854200. Genes Dev. 2000. PMID: 11124802 Free PMC article.
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.
Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E. Oft M, et al. Genes Dev. 1996 Oct 1;10(19):2462-77. doi: 10.1101/gad.10.19.2462. Genes Dev. 1996. PMID: 8843198
IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs.
Emmerich J, Mumm JB, Chan IH, LaFace D, Truong H, McClanahan T, Gorman DM, Oft M. Emmerich J, et al. Among authors: oft m. Cancer Res. 2012 Jul 15;72(14):3570-81. doi: 10.1158/0008-5472.CAN-12-0721. Epub 2012 May 11. Cancer Res. 2012. PMID: 22581824
IL-23 promotes tumour incidence and growth.
Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, Basham B, McClanahan T, Kastelein RA, Oft M. Langowski JL, et al. Among authors: oft m. Nature. 2006 Jul 27;442(7101):461-5. doi: 10.1038/nature04808. Epub 2006 May 10. Nature. 2006. PMID: 16688182
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.
Bevec D, Jaksche H, Oft M, Wöhl T, Himmelspach M, Pacher A, Schebesta M, Koettnitz K, Dobrovnik M, Csonga R, Lottspeich F, Hauber J. Bevec D, et al. Among authors: oft m. Science. 1996 Mar 29;271(5257):1858-60. doi: 10.1126/science.271.5257.1858. Science. 1996. PMID: 8596953
Functional analysis of the human immunodeficiency virus type 1 Rev protein oligomerization interface.
Thomas SL, Oft M, Jaksche H, Casari G, Heger P, Dobrovnik M, Bevec D, Hauber J. Thomas SL, et al. Among authors: oft m. J Virol. 1998 Apr;72(4):2935-44. doi: 10.1128/JVI.72.4.2935-2944.1998. J Virol. 1998. PMID: 9525614 Free PMC article.
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