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The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects.
Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J, Williams R, Lemos R, Oh J, Volgin A, Soghomonyan S, Nishii R, Alauddin M, Mukhopadhay U, Peng Z, Bornmann W, Gelovani J. Schwartz DL, et al. Among authors: oh j. Mol Cancer Ther. 2009 Apr;8(4):947-58. doi: 10.1158/1535-7163.MCT-08-0981. Mol Cancer Ther. 2009. PMID: 19372568 Free PMC article.
HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.
Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin M, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J. Schwartz DL, et al. Among authors: oh j. Mol Cancer Res. 2011 Mar;9(3):259-70. doi: 10.1158/1541-7786.MCR-10-0469. Epub 2011 Mar 1. Mol Cancer Res. 2011. PMID: 21364021 Free PMC article.
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