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Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
Ohkawara B, Glinka A, Niehrs C. Ohkawara B, et al. Dev Cell. 2011 Mar 15;20(3):303-14. doi: 10.1016/j.devcel.2011.01.006. Dev Cell. 2011. PMID: 21397842
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.
Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C. Cruciat CM, et al. Among authors: ohkawara b. Science. 2013 Mar 22;339(6126):1436-41. doi: 10.1126/science.1231499. Epub 2013 Feb 14. Science. 2013. PMID: 23413191
An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos.
Ohkawara B, Niehrs C. Ohkawara B, et al. Dev Dyn. 2011 Jan;240(1):188-94. doi: 10.1002/dvdy.22500. Dev Dyn. 2011. PMID: 21128306
Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.
Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C, Boutros M. Buechling T, et al. Among authors: ohkawara b. Curr Biol. 2010 Jul 27;20(14):1263-8. doi: 10.1016/j.cub.2010.05.028. Epub 2010 Jun 24. Curr Biol. 2010. PMID: 20579883
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C. Kazanskaya O, et al. Among authors: ohkawara b. Development. 2008 Nov;135(22):3655-64. doi: 10.1242/dev.027284. Epub 2008 Oct 8. Development. 2008. PMID: 18842812
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.
Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C. Cruciat CM, et al. Among authors: ohkawara b. Science. 2010 Jan 22;327(5964):459-63. doi: 10.1126/science.1179802. Science. 2010. PMID: 20093472
R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.
Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K. Takegami Y, et al. Among authors: ohkawara b. Biochem Biophys Res Commun. 2016 Apr 22;473(1):255-264. doi: 10.1016/j.bbrc.2016.03.089. Epub 2016 Mar 22. Biochem Biophys Res Commun. 2016. PMID: 27012200
Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.
Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T. Adachi S, et al. Among authors: ohkawara b. Cancer Res. 2004 Dec 1;64(23):8496-501. doi: 10.1158/0008-5472.CAN-04-2254. Cancer Res. 2004. PMID: 15574752
Action range of BMP is defined by its N-terminal basic amino acid core.
Ohkawara B, Iemura S, ten Dijke P, Ueno N. Ohkawara B, et al. Curr Biol. 2002 Feb 5;12(3):205-9. doi: 10.1016/s0960-9822(01)00684-4. Curr Biol. 2002. PMID: 11839272
Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis.
Osawa Y, Matsushita M, Hasegawa S, Esaki R, Fujio M, Ohkawara B, Ishiguro N, Ohno K, Kitoh H. Osawa Y, et al. Among authors: ohkawara b. Bone. 2017 Dec;105:42-49. doi: 10.1016/j.bone.2017.05.016. Epub 2017 Aug 10. Bone. 2017. PMID: 28802681
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