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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage.
Ohta A, Sitkovsky M. Ohta A, et al. Nature. 2001 Dec 20-27;414(6866):916-20. doi: 10.1038/414916a. Nature. 2001. PMID: 11780065
Here we show that A2a adenosine receptors have a non-redundant role in the attenuation of inflammation and tissue damage in vivo. ...We suggest that A2a adenosine receptors are a critical part of the physiological negative feedback mechanism for limitation and termi …
Here we show that A2a adenosine receptors have a non-redundant role in the attenuation of inflammation and tissue damage in vivo. ... …
Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.
Thiel M, Caldwell CC, Kreth S, Kuboki S, Chen P, Smith P, Ohta A, Lentsch AB, Lukashev D, Sitkovsky MV. Thiel M, et al. PLoS One. 2007 Sep 5;2(9):e853. doi: 10.1371/journal.pone.0000853. PLoS One. 2007. PMID: 17786224 Free PMC article.
METHODOLOGY/PRINCIPAL FINDINGS: Using the Cre-lox-P-system we generated mice with a T-cell targeted deletion of the HIF-1alpha gene and analysed them in an in vivo model of bacterial sepsis. ...
METHODOLOGY/PRINCIPAL FINDINGS: Using the Cre-lox-P-system we generated mice with a T-cell targeted deletion of the HIF-1alpha gene a …
The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.
Abbott RK, Silva M, Labuda J, Thayer M, Cain DW, Philbrook P, Sethumadhavan S, Hatfield S, Ohta A, Sitkovsky M. Abbott RK, et al. J Biol Chem. 2017 Jan 27;292(4):1211-1217. doi: 10.1074/jbc.C116.764043. Epub 2016 Dec 14. J Biol Chem. 2017. PMID: 27974461 Free PMC article.
In support of this hypothesis, we found that following immunization, mice lacking A2aR (A2aRKO) exhibited a significant expansion of T follicular cells, as well as increases in T(FH) to T(FR) ratio, GC T cell frequency, GC B cell frequency, and class switching of GC B cell …
In support of this hypothesis, we found that following immunization, mice lacking A2aR (A2aRKO) exhibited a significant expansion of …
Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.
Choukèr A, Thiel M, Lukashev D, Ward JM, Kaufmann I, Apasov S, Sitkovsky MV, Ohta A. Choukèr A, et al. Mol Med. 2008 Mar-Apr;14(3-4):116-23. doi: 10.2119/2007-00075.Chouker. Mol Med. 2008. PMID: 18163162 Free PMC article.
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls inflammatory liver damage and protects the liver using a mouse mo …
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired g …
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.
Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, Lukashev D, Bittmann I, Sitkovsky MV. Thiel M, et al. PLoS Biol. 2005 Jun;3(6):e174. doi: 10.1371/journal.pbio.0030174. Epub 2005 May 3. PLoS Biol. 2005. PMID: 15857155 Free PMC article.
Although oxygen therapy represents a life-saving measure, the recent discovery of a critical tissue-protecting mechanism predicts that administration of oxygen to ARDS patients with uncontrolled pulmonary inflammation also may have dangerous side effects. ...The ide …
Although oxygen therapy represents a life-saving measure, the recent discovery of a critical tissue-protecting mechanism predi …
Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo.
Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M. Lukashev D, et al. J Immunol. 2004 Jul 1;173(1):21-4. doi: 10.4049/jimmunol.173.1.21. J Immunol. 2004. PMID: 15210754
The A2A adenosine receptor plays a critical role in the physiologic immunosuppressive pathway that protects normal tissues from excessive collateral damage by overactive immune cells and their proinflammatory cytokines. ...These observations provide the genetic in vivo evi …
The A2A adenosine receptor plays a critical role in the physiologic immunosuppressive pathway that protects normal tissues from exces …
Targeting hypoxia--A(2A) adenosine receptor-mediated mechanisms of tissue protection.
Lukashev D, Ohta A, Sitkovsky M. Lukashev D, et al. Drug Discov Today. 2004 May 1;9(9):403-9. doi: 10.1016/S1359-6446(04)03044-2. Drug Discov Today. 2004. PMID: 15081957 Review.
The A(2A) adenosine receptor and hypoxia-inducible factor play important roles in the attenuation of proinflammatory processes in a delayed, negative-feedback manner and thus protect organs from excessive damage. Targeting individual stages of the hypoxia-A(2 …
The A(2A) adenosine receptor and hypoxia-inducible factor play important roles in the attenuation of proinflammatory processes in …
Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs.
Lukashev DE, Smith PT, Caldwell CC, Ohta A, Apasov SG, Sitkovsky MV. Lukashev DE, et al. Biochem Pharmacol. 2003 Jun 15;65(12):2081-90. doi: 10.1016/s0006-2952(03)00158-8. Biochem Pharmacol. 2003. PMID: 12787889
Although recent genetic and pharmacologic in vivo studies of acute inflammation models in mice demonstrated that the cyclic AMP-elevating A2a receptor plays a non-redundant role in protection from excessive acute inflammatory tissue damage and in the down-regulation of pro …
Although recent genetic and pharmacologic in vivo studies of acute inflammation models in mice demonstrated that the cyclic AMP-elevating A2 …
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.
Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Sitkovsky MV, et al. Annu Rev Immunol. 2004;22:657-82. doi: 10.1146/annurev.immunol.22.012703.104731. Annu Rev Immunol. 2004. PMID: 15032592 Review.
The search for physiological mechanisms that downregulate activated immune cells has revealed a critical role for extracellular adenosine and for immunosuppressive A2A adenosine receptors in protecting tissue from inflammatory damage. ...The A2A receptor-triggered generati …
The search for physiological mechanisms that downregulate activated immune cells has revealed a critical role for extracellular adeno …
The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?
Sitkovsky MV, Ohta A. Sitkovsky MV, et al. Trends Immunol. 2005 Jun;26(6):299-304. doi: 10.1016/j.it.2005.04.004. Trends Immunol. 2005. PMID: 15922945
The surprisingly low incidence of post-inflammatory complications is explained here by a 'danger-sensing' physiological mechanism that ensures the tissue-protecting negative feedback inhibition of overactive immune cells. ...
The surprisingly low incidence of post-inflammatory complications is explained here by a 'danger-sensing' physiological mechanism tha …
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