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FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
Ohta Y, Hartwig JH, Stossel TP. Ohta Y, et al. Nat Cell Biol. 2006 Aug;8(8):803-14. doi: 10.1038/ncb1437. Epub 2006 Jul 23. Nat Cell Biol. 2006. PMID: 16862148
The role of FilGAP, a Rac-specific Rho-GTPase-activating protein, in tumor progression and behavior of astrocytomas.
Hara A, Hashimura M, Tsutsumi K, Akiya M, Inukai M, Ohta Y, Saegusa M. Hara A, et al. Among authors: ohta y. Cancer Med. 2016 Dec;5(12):3412-3425. doi: 10.1002/cam4.937. Epub 2016 Oct 27. Cancer Med. 2016. PMID: 27790861 Free PMC article.
The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration.
Iida T, Saito K, Katagiri K, Kinashi T, Ohta Y. Iida T, et al. Among authors: ohta y. FEBS Lett. 2016 May;590(10):1395-408. doi: 10.1002/1873-3468.12189. Epub 2016 May 11. FEBS Lett. 2016. PMID: 27130700
FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.
Nishi T, Takahashi H, Hashimura M, Yoshida T, Ohta Y, Saegusa M. Nishi T, et al. Among authors: ohta y. Cancer Med. 2015 Jun;4(6):808-18. doi: 10.1002/cam4.423. Epub 2015 Jan 29. Cancer Med. 2015. PMID: 25641953 Free PMC article.
FilGAP regulates distinct stages of epithelial tubulogenesis.
Zuinen T, Tsutsumi K, Ohta Y. Zuinen T, et al. Among authors: ohta y. Biochem Biophys Res Commun. 2019 Jun 30;514(3):742-749. doi: 10.1016/j.bbrc.2019.04.187. Epub 2019 May 9. Biochem Biophys Res Commun. 2019. PMID: 31078260
Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Uehara S, Saito K, Asami H, Ohta Y. Uehara S, et al. Among authors: ohta y. Anticancer Res. 2017 Sep;37(9):4837-4844. doi: 10.21873/anticanres.11891. Anticancer Res. 2017. PMID: 28870903
Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein.
Morishita Y, Tsutsumi K, Ohta Y. Morishita Y, et al. Among authors: ohta y. J Biol Chem. 2015 Oct 23;290(43):26328-38. doi: 10.1074/jbc.M115.666875. Epub 2015 Sep 10. J Biol Chem. 2015. PMID: 26359494 Free PMC article.
FilGAP, a Rho-ROCK-regulated GAP for Rac, controls adherens junctions in MDCK cells.
Nakahara S, Tsutsumi K, Zuinen T, Ohta Y. Nakahara S, et al. Among authors: ohta y. J Cell Sci. 2015 Jun 1;128(11):2047-56. doi: 10.1242/jcs.160192. Epub 2015 Apr 23. J Cell Sci. 2015. PMID: 25908853
Afadin regulates RhoA/Rho-associated protein kinase signaling to control formation of actin stress fibers in kidney podocytes.
Saito K, Shiino T, Kurihara H, Harita Y, Hattori S, Ohta Y. Saito K, et al. Among authors: ohta y. Cytoskeleton (Hoboken). 2015 Mar;72(3):146-56. doi: 10.1002/cm.21211. Epub 2015 Apr 22. Cytoskeleton (Hoboken). 2015. PMID: 25712270
ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.
Kawaguchi K, Saito K, Asami H, Ohta Y. Kawaguchi K, et al. Among authors: ohta y. J Biol Chem. 2014 Apr 4;289(14):9675-82. doi: 10.1074/jbc.M113.546051. Epub 2014 Feb 13. J Biol Chem. 2014. PMID: 24526684 Free PMC article.
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