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Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells.
Ohtani KI, Shimizu H, Sato N, Mori M. Ohtani KI, et al. Endocrinology. 1998 Jan;139(1):172-8. doi: 10.1210/endo.139.1.5670. Endocrinology. 1998. PMID: 9421412
Glucagon plays an important role in the modification of insulin secretion by leptin.
Shimizu H, Tsuchiya T, Ohtani K, Shimomura K, Oh-I S, Ariyama Y, Okada S, Kishi M, Mori M. Shimizu H, et al. Islets. 2011 Jul-Aug;3(4):150-4. doi: 10.4161/isl.3.4.15733. Epub 2011 Jul 1. Islets. 2011. PMID: 21623172
Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2+-dependent mechanism.
Shimizu H, Ohtani K, Kato Y, Mori M. Shimizu H, et al. J Endocrinol. 2000 Jul;166(1):121-6. doi: 10.1677/joe.0.1660121. J Endocrinol. 2000. PMID: 10856890
Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets.
Shimizu H, Okajima F, Kimura T, Ohtani K, Tsuchiya T, Takahashi H, Kuwabara A, Tomura H, Sato K, Mori M. Shimizu H, et al. Endocr J. 2000 Jun;47(3):261-9. doi: 10.1507/endocrj.47.261. Endocr J. 2000. PMID: 11036869
Identification and characterization of a glucose-responsiveness region upstream of human insulin gene in transfected HIT-T 15 cells.
Ohtani K, Shimizu H, Kato Y, Mori M. Ohtani K, et al. Biochem Biophys Res Commun. 1998 Jan 14;242(2):446-51. doi: 10.1006/bbrc.1997.7980. Biochem Biophys Res Commun. 1998. PMID: 9446815
Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells.
Shimizu H, Ohtani K, Tsuchiya T, Takahashi H, Uehara Y, Sato N, Mori M. Shimizu H, et al. Peptides. 1997;18(8):1263-6. doi: 10.1016/s0196-9781(97)00137-x. Peptides. 1997. PMID: 9396071
Serum leptin concentration is associated with total body fat mass, but not abdominal fat distribution.
Shimizu H, Shimomura Y, Hayashi R, Ohtani K, Sato N, Futawatari T, Mori M. Shimizu H, et al. Int J Obes Relat Metab Disord. 1997 Jul;21(7):536-41. doi: 10.1038/sj.ijo.0800437. Int J Obes Relat Metab Disord. 1997. PMID: 9226482
Pioglitazone hydrochloride stimulates insulin secretion in HIT-T 15 cells by inducing Ca2+ influx.
Ohtani K, Shimizu H, Tanaka Y, Sato N, Mori M. Ohtani K, et al. J Endocrinol. 1996 Jul;150(1):107-11. doi: 10.1677/joe.0.1500107. J Endocrinol. 1996. PMID: 8708551
Acarbose partially prevents the development of diabetes mellitus by multiple low-dose streptozotocin administration.
Negishi M, Shimizu H, Ohtani K, Mori M. Negishi M, et al. Diabetes Res Clin Pract. 1996 Jun;33(1):15-9. doi: 10.1016/0168-8227(96)01254-5. Diabetes Res Clin Pract. 1996. PMID: 8877271
Estrogen increases in vivo leptin production in rats and human subjects.
Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N, Mori M. Shimizu H, et al. J Endocrinol. 1997 Aug;154(2):285-92. doi: 10.1677/joe.0.1540285. J Endocrinol. 1997. PMID: 9291839
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