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Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Yamazaki H, et al. Among authors: ohyama k. Protein Expr Purif. 2002 Apr;24(3):329-37. doi: 10.1006/prep.2001.1578. Protein Expr Purif. 2002. PMID: 11922748
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6.
Shimizu M, Uehara S, Ohyama K, Nishimura H, Tanaka Y, Saito Y, Suemizu H, Yoshida S, Yamazaki H. Shimizu M, et al. Among authors: ohyama k. Drug Metab Dispos. 2023 Oct 25:DMD-AR-2023-001481. doi: 10.1124/dmd.123.001481. Online ahead of print. Drug Metab Dispos. 2023. PMID: 37879849 Free article.
Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.
Adachi K, Ohyama K, Tanaka Y, Saito Y, Shimizu M, Yamazaki H. Adachi K, et al. Among authors: ohyama k. Biol Pharm Bull. 2024;47(3):635-640. doi: 10.1248/bpb.b24-00012. Biol Pharm Bull. 2024. PMID: 38494736 Free article.
760 results