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New aspects of the mechanism of corticosteroid-induced dermal atrophy.
Oikarinen A, Autio P. Oikarinen A, et al. Clin Exp Dermatol. 1991 Nov;16(6):416-9. doi: 10.1111/j.1365-2230.1991.tb01225.x. Clin Exp Dermatol. 1991. PMID: 1806315 Review.
During recent years the effects of glucocorticoids on connective tissue have been elucidated, and it is evident that skin atrophy is mostly due to a decrease in collagen synthesis. ...
During recent years the effects of glucocorticoids on connective tissue have been elucidated, and it is evident that skin atrophy is mostly …
Interleukin 1 alpha (IL-1 alpha) in human skin in vivo: lack of correlation to markers of collagen metabolism.
Kylmäniemi M, Autio P, Oikarinen A. Kylmäniemi M, et al. Among authors: oikarinen a. Acta Derm Venereol. 1994 Sep;74(5):364-7. doi: 10.2340/0001555574364367. Acta Derm Venereol. 1994. PMID: 7817673
Isotretinoin, tetracycline and circulating hormones in acne.
Palatsi R, Ruokonen A, Oikarinen A. Palatsi R, et al. Among authors: oikarinen a. Acta Derm Venereol. 1997 Sep;77(5):394-6. doi: 10.2340/0001555577394396. Acta Derm Venereol. 1997. PMID: 9298137 Clinical Trial.
After 12 weeks of therapy, there was a decrease in the levels of the precursor androgens androstenedione, testosterone and 3 alpha-Adiol G in 6/9 patients. Acne improved after 4.5 months in all but 2 male patients, who had very low serum hormone binding globulins (SHBG) an …
After 12 weeks of therapy, there was a decrease in the levels of the precursor androgens androstenedione, testosterone and 3 alpha-Ad …
Steroid-induced dermal atrophy: effects of glucocorticosteroids on collagen metabolism in human skin fibroblast cultures.
Booth BA, Tan EM, Oikarinen A, Uitto J. Booth BA, et al. Among authors: oikarinen a. Int J Dermatol. 1982 Jul-Aug;21(6):333-7. doi: 10.1111/j.1365-4362.1982.tb03140.x. Int J Dermatol. 1982. PMID: 7118346
The steroids, in a wide concentration range, failed to elicit any consistent alterations in collagen production. Review of the literature dealing with corticosteroid-induced changes in collagen production by human skin fibroblasts indicate conflicting results even under ap …
The steroids, in a wide concentration range, failed to elicit any consistent alterations in collagen production. Review of the litera …
[The effects of ultraviolet light on connective tissue in skin].
Oikarinen A. Oikarinen A. Duodecim. 1990;106(14):1036-44. Duodecim. 1990. PMID: 1670349 Review. Finnish. No abstract available.
Modulation of collagen metabolism by glucocorticoids. Receptor-mediated effects of dexamethasone on collagen biosynthesis in chick embryo fibroblasts and chondrocytes.
Oikarinen AI, Vuorio EI, Zaragoza EJ, Palotie A, Chu ML, Uitto J. Oikarinen AI, et al. Biochem Pharmacol. 1988 Apr 15;37(8):1451-62. doi: 10.1016/0006-2952(88)90006-8. Biochem Pharmacol. 1988. PMID: 3358778
To address the mechanisms of the inhibition of collagen biosynthesis, specific binding of dexamethasone to glucocorticoid receptors in chick embryo tendon and cartilage cells was studied in a whole cell assay using [3H]dexamethasone as the ligand. ...Comparable values were …
To address the mechanisms of the inhibition of collagen biosynthesis, specific binding of dexamethasone to glucocorticoid receptors in chick …
Effect of phenytoin and nifedipine on collagen gene expression in human gingival fibroblasts.
Salo T, Oikarinen KS, Oikarinen AI. Salo T, et al. Among authors: oikarinen ks, oikarinen ai. J Oral Pathol Med. 1990 Oct;19(9):404-7. doi: 10.1111/j.1600-0714.1990.tb00868.x. J Oral Pathol Med. 1990. PMID: 2176691
Phenytoin (PHT), a widely used anticonvulsant, and nifedipine (NF), an anti-anginal drug, cause clinically similar gingival overgrowths in some patients. ...The decrease in the level of type I collagen mRNA seemed to be specific since the level of type IV collagenase mRNA …
Phenytoin (PHT), a widely used anticonvulsant, and nifedipine (NF), an anti-anginal drug, cause clinically similar gingival overgrowt …
Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease.
Saarialho-Kere UK, Vaalamo M, Airola K, Niemi KM, Oikarinen AI, Parks WC. Saarialho-Kere UK, et al. Among authors: oikarinen ai. J Invest Dermatol. 1995 Jun;104(6):982-8. doi: 10.1111/1523-1747.ep12606231. J Invest Dermatol. 1995. PMID: 7539470
Migrating keratinocytes actively involved in reepithelialization in dermal wounds acquire a collagenolytic phenotype upon contact with the dermal matrix. ...Distinct from that seen in chronic ulcers or in normal healing by second intention, reepithelialization in these bli …
Migrating keratinocytes actively involved in reepithelialization in dermal wounds acquire a collagenolytic phenotype upon contact wit …
A thyroid hormone analogue, triiodothyroacetic acid, corrects corticosteroid-downregulated collagen synthesis.
Yazdanparast P, Carlsson B, Oikarinen A, Risteli J, Faergemann J. Yazdanparast P, et al. Among authors: oikarinen a. Thyroid. 2004 May;14(5):345-53. doi: 10.1089/105072504774193168. Thyroid. 2004. PMID: 15186610 Clinical Trial.
Eighteen healthy volunteers were pretreated with BM on abdominal skin for 3 days, and were then treated for 14 days with a cream containing TRIAC (0.03% or 0.1%) or a placebo cream. ...The result suggests a potential role for TRIAC-containing cream concomitan …
Eighteen healthy volunteers were pretreated with BM on abdominal skin for 3 days, and were then treated for 14 days with a cream cont …
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans.
Yazdanparast P, Carlsson B, Oikarinen A, Risteli J, Lavin T, Faergemann J. Yazdanparast P, et al. Among authors: oikarinen a. Thyroid. 2006 Nov;16(11):1157-62. doi: 10.1089/thy.2006.16.1157. Thyroid. 2006. PMID: 17123343 Clinical Trial.
The present study concerns the effect of topical treatment with a cream formulation of triiodothyroacetic acid (TRIAC) in comparison with a placebo preparation in producing a reversal of skin atrophy induced by long-term employment of topical glucocorticoid t …
The present study concerns the effect of topical treatment with a cream formulation of triiodothyroacetic acid (TRIAC) in comparison …
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