Oishi S - Search Results

1

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.

Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC. Fujii N, et al. Among authors: oishi s. Angew Chem Int Ed Engl. 2003 Jul 21;42(28):3251-3. doi: 10.1002/anie.200351024. Angew Chem Int Ed Engl. 2003. PMID: 12876735 No abstract available.

2

Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.

Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: oishi s. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2633-7. doi: 10.1016/s0960-894x(00)00535-7. Bioorg Med Chem Lett. 2000. PMID: 11128640

3

Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.

Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Peiper SC, Hamanaka N, Otaka A, Fujii N. Tamamura H, et al. Among authors: oishi s. Bioorg Med Chem Lett. 2001 Feb 12;11(3):359-62. doi: 10.1016/s0960-894x(00)00664-8. Bioorg Med Chem Lett. 2001. PMID: 11212110

4

Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system.

Ohno H, Miyamura K, Tanaka T, Oishi S, Toda A, Takemoto Y, Fujii N, Ibuka T. Ohno H, et al. Among authors: oishi s. J Org Chem. 2002 Feb 22;67(4):1359-67. doi: 10.1021/jo016320y. J Org Chem. 2002. PMID: 11846687

5

Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.

Tamamura H, Omagari A, Hiramatsu K, Oishi S, Habashita H, Kanamoto T, Gotoh K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: oishi s. Bioorg Med Chem. 2002 May;10(5):1417-26. doi: 10.1016/s0968-0896(01)00419-9. Bioorg Med Chem. 2002. PMID: 11886804

6

Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction.

Oishi S, Kamano T, Niida A, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N. Oishi S, et al. Org Lett. 2002 Apr 4;4(7):1051-4. doi: 10.1021/ol016834j. Org Lett. 2002. PMID: 11922780

7

Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction.

Oishi S, Niida A, Kamano T, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N. Oishi S, et al. Org Lett. 2002 Apr 4;4(7):1055-8. doi: 10.1021/ol016835b. Org Lett. 2002. PMID: 11922781

8

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.

Tamamura H, Hiramatsu K, Miyamoto K, Omagari A, Oishi S, Nakashima H, Yamamoto N, Kuroda Y, Nakagawa T, Otaka A, Fujii N. Tamamura H, et al. Among authors: oishi s. Bioorg Med Chem Lett. 2002 Mar 25;12(6):923-8. doi: 10.1016/s0960-894x(02)00041-0. Bioorg Med Chem Lett. 2002. PMID: 11958995

9

Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions.

Otaka A, Katagiri F, Kinoshita T, Odagaki Y, Oishi S, Tamamura H, Hamanaka N, Fujii N. Otaka A, et al. Among authors: oishi s. J Org Chem. 2002 Aug 23;67(17):6152-61. doi: 10.1021/jo025922u. J Org Chem. 2002. PMID: 12182656

10

Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics.

Oishi S, Kamano T, Niida A, Odagaki Y, Hamanaka N, Yamamoto M, Ajito K, Tamamura H, Otaka A, Fujii N. Oishi S, et al. J Org Chem. 2002 Aug 23;67(17):6162-73. doi: 10.1021/jo025923m. J Org Chem. 2002. PMID: 12182657

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