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Cellular mechanisms of subplate-driven and cholinergic input-dependent network activity in the neonatal rat somatosensory cortex.
Hanganu IL, Okabe A, Lessmann V, Luhmann HJ. Hanganu IL, et al. Cereb Cortex. 2009 Jan;19(1):89-105. doi: 10.1093/cercor/bhn061. Epub 2008 Apr 24. Cereb Cortex. 2009. PMID: 18440948
Correspondingly, endogenous or agonist-induced activation of predominantly m1/m5-assembled muscarinic acetylcholine receptors elicits bursts of action potentials (up states) as a result of suprathreshold activation of the subplate. ...
Correspondingly, endogenous or agonist-induced activation of predominantly m1/m5-assembled muscarinic acetylcholine receptors elicits bursts …
Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus.
Chen R, Okabe A, Sun H, Sharopov S, Hanganu-Opatz IL, Kolbaev SN, Fukuda A, Luhmann HJ, Kilb W. Chen R, et al. J Physiol. 2014 May 15;592(10):2153-68. doi: 10.1113/jphysiol.2014.271700. Epub 2014 Mar 24. J Physiol. 2014. PMID: 24665103 Free PMC article.
We conclude from these results that in the immature hippocampus, activation of glycine receptors can mediate both pro- and anticonvulsive effects, but that a persistent activation of glycine receptors is required to suppress epileptiform activity. ...
We conclude from these results that in the immature hippocampus, activation of glycine receptors can mediate both pro- and anticonvulsive ef …
Kinetic properties of Cl uptake mediated by Na+-dependent K+-2Cl cotransport in immature rat neocortical neurons.
Achilles K, Okabe A, Ikeda M, Shimizu-Okabe C, Yamada J, Fukuda A, Luhmann HJ, Kilb W. Achilles K, et al. J Neurosci. 2007 Aug 8;27(32):8616-27. doi: 10.1523/JNEUROSCI.5041-06.2007. J Neurosci. 2007. PMID: 17687039 Free PMC article.
Although it is well accepted that depolarizing GABA actions are caused by an elevated intracellular Cl- concentration ([Cl-]i), the mechanisms of Cl- accumulation in immature neurons are still a matter of debate. ...Gramicidin-perforated patch-clamp and 6-methoxy-N-ethylqu …
Although it is well accepted that depolarizing GABA actions are caused by an elevated intracellular Cl- concentration ([Cl-]i), the mechanis …
Differential development of cation-chloride cotransporters and Cl- homeostasis contributes to differential GABAergic actions between developing rat visual cortex and dorsal lateral geniculate nucleus.
Ikeda M, Toyoda H, Yamada J, Okabe A, Sato K, Hotta Y, Fukuda A. Ikeda M, et al. Brain Res. 2003 Sep 12;984(1-2):149-59. doi: 10.1016/s0006-8993(03)03126-3. Brain Res. 2003. PMID: 12932849
A recent study suggested that gamma-aminobutyric acid (GABA) plays differential roles in activity-dependent plasticity between the visual cortex (VC) and the dorsal lateral geniculate nucleus (dLGN). ...This suggests that extrusion of Cl(-) from neurons is stronger in dLGN
A recent study suggested that gamma-aminobutyric acid (GABA) plays differential roles in activity-dependent plasticity between the vi
Induction of NMDA and GABAA receptor-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons.
Toyoda H, Ohno K, Yamada J, Ikeda M, Okabe A, Sato K, Hashimoto K, Fukuda A. Toyoda H, et al. J Neurophysiol. 2003 Mar;89(3):1353-62. doi: 10.1152/jn.00721.2002. Epub 2002 Nov 13. J Neurophysiol. 2003. PMID: 12612004
To clarify the changes that occur in gamma-aminobutyric acid type A (GABA(A)) receptor-mediated effects and contribute to alterations in the network activities after neuronal injury, we studied intracellular Ca(2+) concentration ([Ca(2+)](i)) dynamics in a ra …
To clarify the changes that occur in gamma-aminobutyric acid type A (GABA(A)) receptor-mediated effects and contribute to alte …
Amygdala kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex.
Okabe A, Ohno K, Toyoda H, Yokokura M, Sato K, Fukuda A. Okabe A, et al. Neurosci Res. 2002 Oct;44(2):225-9. doi: 10.1016/s0168-0102(02)00093-7. Neurosci Res. 2002. PMID: 12354637
GABA, the main inhibitory neurotransmitter in the brain, elicits a hyperpolarizing response by activation of the GABA(A)-receptor/chloride-channel complex under conditions of normal Cl(-) homeostasis. Thus the pathogenesis of epilepsy could involve an impairment of …
GABA, the main inhibitory neurotransmitter in the brain, elicits a hyperpolarizing response by activation of the GABA(A)-recep …
Differential functional expression of cation-Cl- cotransporter mRNAs (KCC1, KCC2, and NKCC1) in rat trigeminal nervous system.
Toyoda H, Yamada J, Ueno S, Okabe A, Kato H, Sato K, Hashimoto K, Fukuda A. Toyoda H, et al. Brain Res Mol Brain Res. 2005 Jan 5;133(1):12-8. doi: 10.1016/j.molbrainres.2004.09.015. Brain Res Mol Brain Res. 2005. PMID: 15661361
KCC2-mediated regulation of respiration-related rhythmic activity during postnatal development in mouse medulla oblongata.
Okabe A, Shimizu-Okabe C, Arata A, Konishi S, Fukuda A, Takayama C. Okabe A, et al. Brain Res. 2015 Mar 19;1601:31-9. doi: 10.1016/j.brainres.2015.01.007. Epub 2015 Jan 14. Brain Res. 2015. PMID: 25596421
This shift in GABA's action from excitation to inhibition is caused by a decrease in intracellular chloride concentration ([Cl(-)]i), which in turn is caused by changes in the relative expression levels of the K(+)-Cl(-) co-transporter (KCC2) and the Na(+), K(+)-2Cl(-) co- …
This shift in GABA's action from excitation to inhibition is caused by a decrease in intracellular chloride concentration ([Cl(-)]i), …
Changes in the expression of cation-Cl- cotransporters, NKCC1 and KCC2, during cortical malformation induced by neonatal freeze-lesion.
Shimizu-Okabe C, Okabe A, Kilb W, Sato K, Luhmann HJ, Fukuda A. Shimizu-Okabe C, et al. Neurosci Res. 2007 Nov;59(3):288-95. doi: 10.1016/j.neures.2007.07.010. Epub 2007 Aug 13. Neurosci Res. 2007. PMID: 17904674
Focal cortical malformations comprise a heterogeneous group of disturbances in brain development, often associated with intractable epilepsy. A focal freeze-lesion of cerebral cortex in newborn rat produces a cortical malformation that resembles human polymic …
Focal cortical malformations comprise a heterogeneous group of disturbances in brain development, often associated with intractable e …
Diversity of neuron-specific K+-Cl- cotransporter expression and inhibitory postsynaptic potential depression in rat motoneurons.
Ueno T, Okabe A, Akaike N, Fukuda A, Nabekura J. Ueno T, et al. J Biol Chem. 2002 Feb 15;277(7):4945-50. doi: 10.1074/jbc.M109439200. Epub 2001 Dec 3. J Biol Chem. 2002. PMID: 11733521
Motoneurons receive a robust recurrent synaptic inhibition by gamma-aminobutyric acid and glycine, which activate Cl(-) channels. ...This raises a general interest in the correlation between KCC2 expression and inhibitory postsynaptic potential (IPSP) performance in …
Motoneurons receive a robust recurrent synaptic inhibition by gamma-aminobutyric acid and glycine, which activate Cl(-) channels. ... …
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