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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW. Hirao A, et al. Among authors: okada h. Mol Cell Biol. 2002 Sep;22(18):6521-32. doi: 10.1128/mcb.22.18.6521-6532.2002. Mol Cell Biol. 2002. PMID: 12192050 Free PMC article.
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW. Suh WK, et al. Among authors: okada h. Nat Immunol. 2003 Sep;4(9):899-906. doi: 10.1038/ni967. Epub 2003 Aug 17. Nat Immunol. 2003. PMID: 12925852
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Tsuchihara K, et al. Among authors: okada h. Cancer Res. 2005 Aug 1;65(15):6685-91. doi: 10.1158/0008-5472.CAN-04-4223. Cancer Res. 2005. PMID: 16061649
Generation and characterization of Smac/DIABLO-deficient mice.
Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW. Okada H, et al. Mol Cell Biol. 2002 May;22(10):3509-17. doi: 10.1128/mcb.22.10.3509-3517.2002. Mol Cell Biol. 2002. PMID: 11971981 Free PMC article.
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