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Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
Enroth C, Eger BT, Okamoto K, Nishino T, Nishino T, Pai EF. Enroth C, et al. Among authors: okamoto k. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10723-8. doi: 10.1073/pnas.97.20.10723. Proc Natl Acad Sci U S A. 2000. PMID: 11005854 Free PMC article.
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase.
Nishino T, Okamoto K, Kawaguchi Y, Matsumura T, Eger BT, Pai EF, Nishino T. Nishino T, et al. Among authors: okamoto k. FEBS J. 2015 Aug;282(16):3075-90. doi: 10.1111/febs.13277. Epub 2015 Apr 13. FEBS J. 2015. PMID: 25817260 Free PMC article.
[Inhibitors of xanthine oxidoreductase].
Okamoto K. Okamoto K. Nihon Rinsho. 2008 Apr;66(4):748-53. Nihon Rinsho. 2008. PMID: 18409526 Review. Japanese.
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase.
Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T. Nishino T, et al. Among authors: okamoto k. FEBS J. 2008 Jul;275(13):3278-89. doi: 10.1111/j.1742-4658.2008.06489.x. Epub 2008 May 30. FEBS J. 2008. PMID: 18513323 Review.
Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans.
Ichida K, Amaya Y, Okamoto K, Nishino T. Ichida K, et al. Among authors: okamoto k. Int J Mol Sci. 2012 Nov 21;13(11):15475-95. doi: 10.3390/ijms131115475. Int J Mol Sci. 2012. PMID: 23203137 Free PMC article. Review.
Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors: allopurinol, febuxostat, and FYX-051.
Okamoto K, Nishino T. Okamoto K, et al. J Nippon Med Sch. 2008 Feb;75(1):2-3. doi: 10.1272/jnms.75.2. J Nippon Med Sch. 2008. PMID: 18360072
Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase.
Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T. Asai R, et al. Among authors: okamoto k. J Biochem. 2007 Apr;141(4):525-34. doi: 10.1093/jb/mvm054. Epub 2007 Feb 14. J Biochem. 2007. PMID: 17301076
Protein conformational gating of enzymatic activity in xanthine oxidoreductase.
Ishikita H, Eger BT, Okamoto K, Nishino T, Pai EF. Ishikita H, et al. Among authors: okamoto k. J Am Chem Soc. 2012 Jan 18;134(2):999-1009. doi: 10.1021/ja207173p. Epub 2011 Dec 29. J Am Chem Soc. 2012. PMID: 22145797 Free PMC article.
Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T. Okamoto K, et al. J Am Chem Soc. 2010 Dec 8;132(48):17080-3. doi: 10.1021/ja1077574. Epub 2010 Nov 15. J Am Chem Soc. 2010. PMID: 21077683
Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.
Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T. Okamoto K, et al. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):888-93. doi: 10.1080/15257770802146577. Nucleosides Nucleotides Nucleic Acids. 2008. PMID: 18600558
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