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The possible role of bcl-2 expression in the progression of tumors of the uterine cervix.
Saegusa M, Takano Y, Hashimura M, Shoji Y, Okayasu I. Saegusa M, et al. Cancer. 1995 Dec 1;76(11):2297-303. doi: 10.1002/1097-0142(19951201)76:11<2297::aid-cncr2820761118>3.0.co;2-b. Cancer. 1995. PMID: 8635035

RESULTS: bcl-2 immunoreactivity was found in 17 of 46 (37%) CIN I/II, 48 of 75 (64%) CIN III, and 12 of 60 (20%) ISCC, the positivity in CIN III being significantly higher than in CIN I/II or ISCC (P < 0.004, P = 0.0001). ...In the Bax or HPV-DNA positive groups,

RESULTS: bcl-2 immunoreactivity was found in 17 of 46 (37%) CIN I/II, 48 of 75 (64%) CIN III, and 12 of 60 (20%) ISCC, the positivity …
Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and gender.
Umeto H, Yoshida T, Araki K, Yagishita H, Mikami T, Okayasu I. Umeto H, et al. J Gastroenterol. 2009;44(10):1036-45. doi: 10.1007/s00535-009-0103-1. Epub 2009 Jul 11. J Gastroenterol. 2009. PMID: 19590931
Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.
Mikami T, Yoshida T, Numata Y, Shiraishi H, Araki K, Guiot MC, Jass JR, Okayasu I. Mikami T, et al. Am J Clin Pathol. 2007 Mar;127(3):366-73. doi: 10.1309/RFETXN6387KLQ1LD. Am J Clin Pathol. 2007. PMID: 17276933
Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the left- than right-side colorectum.
Okayasu I, Hana K, Tsuruta T, Okamura N, Ogawa T, Tokuyama W, Kajita S, Yoshida T, Mikami T. Okayasu I, et al. Cancer Sci. 2006 May;97(5):362-7. doi: 10.1111/j.1349-7006.2006.00181.x. Cancer Sci. 2006. PMID: 16630132
Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota.
Goedert JJ, Hua X, Bielecka A, Okayasu I, Milne GL, Jones GS, Fujiwara M, Sinha R, Wan Y, Xu X, Ravel J, Shi J, Palm NW, Feigelson HS. Goedert JJ, et al. Among authors: okayasu i. Br J Cancer. 2018 Feb 20;118(4):471-479. doi: 10.1038/bjc.2017.435. Epub 2018 Jan 23. Br J Cancer. 2018. PMID: 29360814 Free PMC article.
Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas.
Nagashio R, Sato Y, Matsumoto T, Kageyama T, Satoh Y, Shinichiro R, Masuda N, Goshima N, Jiang SX, Okayasu I. Nagashio R, et al. Lung Cancer. 2010 Jul;69(1):54-9. doi: 10.1016/j.lungcan.2009.09.015. Epub 2009 Nov 4. Lung Cancer. 2010. PMID: 19892429
Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix.
Ishimi Y, Okayasu I, Kato C, Kwon HJ, Kimura H, Yamada K, Song SY. Ishimi Y, et al. Eur J Biochem. 2003 Mar;270(6):1089-101. doi: 10.1046/j.1432-1033.2003.03440.x. Eur J Biochem. 2003. PMID: 12631269
hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors.
Jiang SX, Kameya T, Asamura H, Umezawa A, Sato Y, Shinada J, Kawakubo Y, Igarashi T, Nagai K, Okayasu I. Jiang SX, et al. Mod Pathol. 2004 Feb;17(2):222-9. doi: 10.1038/modpathol.3800038. Mod Pathol. 2004. PMID: 14657947
Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Koizumi W, Okayasu I, Hyodo I, Sakamoto J, Kojima H; Clinical Study Group of Capecitabine. Koizumi W, et al. Anticancer Drugs. 2008 Sep;19(8):819-24. doi: 10.1097/CAD.0b013e3283094b5d. Anticancer Drugs. 2008. PMID: 18690094 Clinical Trial.
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