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The PD-1-PD-L pathway in immunological tolerance.
Okazaki T, Honjo T. Okazaki T, et al. Trends Immunol. 2006 Apr;27(4):195-201. doi: 10.1016/j.it.2006.02.001. Epub 2006 Feb 24. Trends Immunol. 2006. PMID: 16500147 Review.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T. Freeman GJ, et al. Among authors: okazaki t. J Exp Med. 2000 Oct 2;192(7):1027-34. doi: 10.1084/jem.192.7.1027. J Exp Med. 2000. PMID: 11015443 Free PMC article.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. Latchman Y, et al. Among authors: okazaki t. Nat Immunol. 2001 Mar;2(3):261-8. doi: 10.1038/85330. Nat Immunol. 2001. PMID: 11224527
Microanatomical localization of PD-1 in human tonsils.
Iwai Y, Okazaki T, Nishimura H, Kawasaki A, Yagita H, Honjo T. Iwai Y, et al. Among authors: okazaki t. Immunol Lett. 2002 Oct 1;83(3):215-20. doi: 10.1016/s0165-2478(02)00088-3. Immunol Lett. 2002. PMID: 12095712
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