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26 results
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Advancing antibody drug conjugation: from the laboratory to a clinically approved anticancer drug.
Okeley NM, Alley SC, Senter PD. Okeley NM, et al. Hematol Oncol Clin North Am. 2014 Feb;28(1):13-25. doi: 10.1016/j.hoc.2013.10.009. Hematol Oncol Clin North Am. 2014. PMID: 24287064 Review.
Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability.
Sussman D, Westendorf L, Meyer DW, Leiske CI, Anderson M, Okeley NM, Alley SC, Lyon R, Sanderson RJ, Carter PJ, Benjamin DR. Sussman D, et al. Among authors: okeley nm. Protein Eng Des Sel. 2018 Feb 1;31(2):47-54. doi: 10.1093/protein/gzx067. Protein Eng Des Sel. 2018. PMID: 29370435
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas.
Gerber HP, Kung-Sutherland M, Stone I, Morris-Tilden C, Miyamoto J, McCormick R, Alley SC, Okeley N, Hayes B, Hernandez-Ilizaliturri FJ, McDonagh CF, Carter PJ, Benjamin D, Grewal IS. Gerber HP, et al. Blood. 2009 Apr 30;113(18):4352-61. doi: 10.1182/blood-2008-09-179143. Epub 2009 Jan 15. Blood. 2009. PMID: 19147785
Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates.
Burke PJ, Hamilton JZ, Jeffrey SC, Hunter JH, Doronina SO, Okeley NM, Miyamoto JB, Anderson ME, Stone IJ, Ulrich ML, Simmons JK, McKinney EE, Senter PD, Lyon RP. Burke PJ, et al. Among authors: okeley nm. Mol Cancer Ther. 2017 Jan;16(1):116-123. doi: 10.1158/1535-7163.MCT-16-0343. Epub 2016 Nov 9. Mol Cancer Ther. 2017. PMID: 28062707 Free article.
Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Li F, Emmerton KK, Jonas M, Zhang X, Miyamoto JB, Setter JR, Nicholas ND, Okeley NM, Lyon RP, Benjamin DR, Law CL. Li F, et al. Among authors: okeley nm. Cancer Res. 2016 May 1;76(9):2710-9. doi: 10.1158/0008-5472.CAN-15-1795. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921341 Free article.
Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation.
Okeley NM, Toki BE, Zhang X, Jeffrey SC, Burke PJ, Alley SC, Senter PD. Okeley NM, et al. Bioconjug Chem. 2013 Oct 16;24(10):1650-5. doi: 10.1021/bc4002695. Epub 2013 Sep 19. Bioconjug Chem. 2013. PMID: 24050213
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.
Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, Okeley NM, Sanderson RJ, Stone IJ, Zeng W, Gregson SJ, Masterson L, Tiberghien AC, Howard PW, Thurston DE, Law CL, Senter PD. Jeffrey SC, et al. Among authors: okeley nm. Bioconjug Chem. 2013 Jul 17;24(7):1256-63. doi: 10.1021/bc400217g. Epub 2013 Jun 28. Bioconjug Chem. 2013. PMID: 23808985
Development of orally active inhibitors of protein and cellular fucosylation.
Okeley NM, Alley SC, Anderson ME, Boursalian TE, Burke PJ, Emmerton KM, Jeffrey SC, Klussman K, Law CL, Sussman D, Toki BE, Westendorf L, Zeng W, Zhang X, Benjamin DR, Senter PD. Okeley NM, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5404-9. doi: 10.1073/pnas.1222263110. Epub 2013 Mar 14. Proc Natl Acad Sci U S A. 2013. PMID: 23493549 Free PMC article.
Antibody-drug conjugates: targeted drug delivery for cancer.
Alley SC, Okeley NM, Senter PD. Alley SC, et al. Among authors: okeley nm. Curr Opin Chem Biol. 2010 Aug;14(4):529-37. doi: 10.1016/j.cbpa.2010.06.170. Epub 2010 Jul 17. Curr Opin Chem Biol. 2010. PMID: 20643572 Review.
Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate.
Okeley NM, Miyamoto JB, Zhang X, Sanderson RJ, Benjamin DR, Sievers EL, Senter PD, Alley SC. Okeley NM, et al. Clin Cancer Res. 2010 Feb 1;16(3):888-97. doi: 10.1158/1078-0432.CCR-09-2069. Epub 2010 Jan 19. Clin Cancer Res. 2010. PMID: 20086002
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