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The PI3K p110delta controls T-cell development, differentiation and regulation.
Patton DT, Garçon F, Okkenhaug K. Patton DT, et al. Among authors: okkenhaug k. Biochem Soc Trans. 2007 Apr;35(Pt 2):167-71. doi: 10.1042/BST0350167. Biochem Soc Trans. 2007. PMID: 17371229 Review.
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Katso R, et al. Among authors: okkenhaug k. Annu Rev Cell Dev Biol. 2001;17:615-75. doi: 10.1146/annurev.cellbio.17.1.615. Annu Rev Cell Dev Biol. 2001. PMID: 11687500 Review.
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E, Pearce W, Meek SE, Salpekar A, Waterfield MD, Smith AJ, Vanhaesebroeck B. Okkenhaug K, et al. Science. 2002 Aug 9;297(5583):1031-4. doi: 10.1126/science.1073560. Epub 2002 Jul 18. Science. 2002. PMID: 12130661
PI3K-signalling in B- and T-cells: insights from gene-targeted mice.
Okkenhaug K, Vanhaesebroeck B. Okkenhaug K, et al. Biochem Soc Trans. 2003 Feb;31(Pt 1):270-4. doi: 10.1042/bst0310270. Biochem Soc Trans. 2003. PMID: 12546700 Review.
PI3K in lymphocyte development, differentiation and activation.
Okkenhaug K, Vanhaesebroeck B. Okkenhaug K, et al. Nat Rev Immunol. 2003 Apr;3(4):317-30. doi: 10.1038/nri1056. Nat Rev Immunol. 2003. PMID: 12669022 Review.
Phosphoinositide 3-kinase in T cell activation and survival.
Okkenhaug K, Bilancio A, Emery JL, Vanhaesebroeck B. Okkenhaug K, et al. Biochem Soc Trans. 2004 Apr;32(Pt 2):332-5. doi: 10.1042/bst0320332. Biochem Soc Trans. 2004. PMID: 15046602 Review.
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.
Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B. Ali K, et al. Among authors: okkenhaug k. Nature. 2004 Oct 21;431(7011):1007-11. doi: 10.1038/nature02991. Nature. 2004. PMID: 15496927
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Condliffe AM, et al. Among authors: okkenhaug k. Blood. 2005 Aug 15;106(4):1432-40. doi: 10.1182/blood-2005-03-0944. Epub 2005 May 5. Blood. 2005. PMID: 15878979
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.
Bilancio A, Okkenhaug K, Camps M, Emery JL, Ruckle T, Rommel C, Vanhaesebroeck B. Bilancio A, et al. Among authors: okkenhaug k. Blood. 2006 Jan 15;107(2):642-50. doi: 10.1182/blood-2005-07-3041. Epub 2005 Sep 22. Blood. 2006. PMID: 16179367
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells.
Okkenhaug K, Patton DT, Bilancio A, Garçon F, Rowan WC, Vanhaesebroeck B. Okkenhaug K, et al. J Immunol. 2006 Oct 15;177(8):5122-8. doi: 10.4049/jimmunol.177.8.5122. J Immunol. 2006. PMID: 17015696
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