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DNA damage is able to induce senescence in tumor cells in vitro and in vivo.
te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. te Poele RH, et al. Among authors: okorokov al. Cancer Res. 2002 Mar 15;62(6):1876-83. Cancer Res. 2002. PMID: 11912168
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.
Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, Williams GH. Tudzarova S, et al. Among authors: okorokov al. Cell Cycle. 2016 Nov;15(21):2958-2972. doi: 10.1080/15384101.2016.1231281. Epub 2016 Sep 9. Cell Cycle. 2016. PMID: 27611229 Free PMC article.
Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance.
Aramayo R, Sherman MB, Brownless K, Lurz R, Okorokov AL, Orlova EV. Aramayo R, et al. Among authors: okorokov al. Nucleic Acids Res. 2011 Nov 1;39(20):8960-71. doi: 10.1093/nar/gkr386. Epub 2011 Jul 14. Nucleic Acids Res. 2011. PMID: 21764777 Free PMC article.
Two p53 tetramers bind one consensus DNA response element.
Kearns S, Lurz R, Orlova EV, Okorokov AL. Kearns S, et al. Among authors: okorokov al. Nucleic Acids Res. 2016 Jul 27;44(13):6185-99. doi: 10.1093/nar/gkw215. Epub 2016 Mar 31. Nucleic Acids Res. 2016. PMID: 27034469 Free PMC article.
Proteolytic cleavage of p53 mutants in response to mismatched DNA.
Mee T, Okorokov AL, Metcalfe S, Milner J. Mee T, et al. Among authors: okorokov al. Br J Cancer. 1999 Sep;81(2):212-8. doi: 10.1038/sj.bjc.6690679. Br J Cancer. 1999. PMID: 10496344 Free PMC article.
The 35-kDa cleavage product is activated for specific biochemical function(s) and may play a role in the cellular response to DNA damage (Molinari et al (1996) Oncogene 13: 2077-2086; Okorokov et al (1997) EMBO J 16: 6008-6017). ...
The 35-kDa cleavage product is activated for specific biochemical function(s) and may play a role in the cellular response to DNA damage (Mo …
Proteolytic cleavage of p53: a model for the activation of p53 in response to DNA damage.
Okorokov AL, Milner J. Okorokov AL, et al. Oncol Res. 1997;9(6-7):267-73. Oncol Res. 1997. PMID: 9406231 Review.
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells.
te Poele RH, Okorokov AL, Joel SP. te Poele RH, et al. Among authors: okorokov al. Oncogene. 1999 Oct 14;18(42):5765-72. doi: 10.1038/sj.onc.1202961. Oncogene. 1999. PMID: 10523857
p53 in a crosstalk between DNA repair and cell cycle checkpoints.
Okorokov AL. Okorokov AL. Cell Cycle. 2003 May-Jun;2(3):233-5. Cell Cycle. 2003. PMID: 12734432 Review. No abstract available.
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
Fatoba ST, Okorokov AL. Fatoba ST, et al. Among authors: okorokov al. Cell Cycle. 2011 Jul 15;10(14):2317-22. doi: 10.4161/cc.10.14.15913. Epub 2011 Jul 15. Cell Cycle. 2011. PMID: 21636977
Molecular structure of human geminin.
Okorokov AL, Orlova EV, Kingsbury SR, Bagneris C, Gohlke U, Williams GH, Stoeber K. Okorokov AL, et al. Nat Struct Mol Biol. 2004 Oct;11(10):1021-2. doi: 10.1038/nsmb835. Epub 2004 Sep 19. Nat Struct Mol Biol. 2004. PMID: 15378034
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