Oksenberg D - Search Results

1

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.

Metcalf B, Chuang C, Dufu K, Patel MP, Silva-Garcia A, Johnson C, Lu Q, Partridge JR, Patskovska L, Patskovsky Y, Almo SC, Jacobson MP, Hua L, Xu Q, Gwaltney SL 2nd, Yee C, Harris J, Morgan BP, James J, Xu D, Hutchaleelaha A, Paulvannan K, Oksenberg D, Li Z. Metcalf B, et al. Among authors: oksenberg d. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326. doi: 10.1021/acsmedchemlett.6b00491. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337324 Free PMC article.

2

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.

Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53. doi: 10.1111/bjh.14214. Epub 2016 Jul 5. Br J Haematol. 2016. PMID: 27378309 Free article.

3

Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis.

Geng X, Dufu K, Hutchaleelaha A, Xu Q, Li Z, Li CM, Patel MP, Vlahakis N, Lehrer-Graiwer J, Oksenberg D. Geng X, et al. Among authors: oksenberg d. Physiol Rep. 2016 Sep;4(17):e12965. doi: 10.14814/phy2.12965. Physiol Rep. 2016. PMID: 27624688 Free PMC article.

4

GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise.

Dufu K, Lehrer-Graiwer J, Ramos E, Oksenberg D. Dufu K, et al. Among authors: oksenberg d. Hematol Rep. 2016 Sep 28;8(3):6637. doi: 10.4081/hr.2016.6637. eCollection 2016 Sep 28. Hematol Rep. 2016. PMID: 27757216 Free PMC article.

5

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

Dufu K, Patel M, Oksenberg D, Cabrales P. Dufu K, et al. Among authors: oksenberg d. Clin Hemorheol Microcirc. 2018;70(1):95-105. doi: 10.3233/CH-170340. Clin Hemorheol Microcirc. 2018. PMID: 29660913 Free PMC article.

6

Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin-oxygen affinity modifiers.

Patel MP, Siu V, Silva-Garcia A, Xu Q, Li Z, Oksenberg D. Patel MP, et al. Among authors: oksenberg d. Drug Des Devel Ther. 2018 Jun 1;12:1599-1607. doi: 10.2147/DDDT.S157570. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 29910606 Free PMC article.

7

GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro.

Dufu K, Oksenberg D. Dufu K, et al. Among authors: oksenberg d. Hematol Rep. 2018 May 14;10(2):7419. doi: 10.4081/hr.2018.7419. eCollection 2018 May 14. Hematol Rep. 2018. PMID: 30046411 Free PMC article.

8

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease.

Hutchaleelaha A, Patel M, Washington C, Siu V, Allen E, Oksenberg D, Gretler DD, Mant T, Lehrer-Graiwer J. Hutchaleelaha A, et al. Among authors: oksenberg d. Br J Clin Pharmacol. 2019 Jun;85(6):1290-1302. doi: 10.1111/bcp.13896. Epub 2019 Mar 31. Br J Clin Pharmacol. 2019. PMID: 30743314 Free PMC article. Clinical Trial.

9

Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.

Dufu K, Williams AT, Muller CR, Walser CM, Lucas A, Eaker AM, Alt C, Cathers BE, Oksenberg D, Cabrales P. Dufu K, et al. Among authors: oksenberg d. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H400-H411. doi: 10.1152/ajpheart.00048.2021. Epub 2021 Jul 2. Am J Physiol Heart Circ Physiol. 2021. PMID: 34213392 Free PMC article.

10

GBT1118, a potent allosteric modifier of hemoglobin O₂ affinity, increases tolerance to severe hypoxia in mice.

Dufu K, Yalcin O, Ao-Ieong ESY, Hutchaleelala A, Xu Q, Li Z, Vlahakis N, Oksenberg D, Lehrer-Graiwer J, Cabrales P. Dufu K, et al. Among authors: oksenberg d. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H381-H391. doi: 10.1152/ajpheart.00772.2016. Epub 2017 May 19. Am J Physiol Heart Circ Physiol. 2017. PMID: 28526710 Free PMC article.

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