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A structurally abnormal insulin causing human diabetes.
Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R. Tager H, et al. Among authors: olefsky j. Nature. 1979 Sep 13;281(5727):122-5. doi: 10.1038/281122a0. Nature. 1979. PMID: 381941
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.
Ciaraldi TP, el-Roeiy A, Madar Z, Reichart D, Olefsky JM, Yen SS. Ciaraldi TP, et al. Among authors: olefsky jm. J Clin Endocrinol Metab. 1992 Aug;75(2):577-83. doi: 10.1210/jcem.75.2.1322430. J Clin Endocrinol Metab. 1992. PMID: 1322430
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.
Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM. Suter SL, et al. Among authors: olefsky jm. Diabetes Care. 1992 Feb;15(2):193-203. doi: 10.2337/diacare.15.2.193. Diabetes Care. 1992. PMID: 1547676
Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.
Takata Y, Webster NJ, Olefsky JM. Takata Y, et al. Among authors: olefsky jm. J Biol Chem. 1992 May 5;267(13):9065-70. J Biol Chem. 1992. PMID: 1577744
., and Olefsky, J. M. (1991) J. Biol. Chem. 266, 9135-9139). In this paper, we present further evidence for the divergence of the metabolic and mitogenic signaling pathways utilized by the insulin receptor. ...
., and Olefsky, J. M. (1991) J. Biol. Chem. 266, 9135-9139). In this paper, we present further evidence for the divergence of the met …
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.
Kusari J, Verma US, Buse JB, Henry RR, Olefsky JM. Kusari J, et al. Among authors: olefsky jm. J Clin Invest. 1991 Oct;88(4):1323-30. doi: 10.1172/JCI115437. J Clin Invest. 1991. PMID: 1918382 Free PMC article.
Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.
Takata Y, Webster NJ, Olefsky JM. Takata Y, et al. Among authors: olefsky jm. J Biol Chem. 1991 May 15;266(14):9135-9. J Biol Chem. 1991. PMID: 2026614
., and Olefsky, J. M. (1988) J. Biol. Chem. 263, 8904-8911; Thies, R.S., Ulrich, A., and McClain, D. A. (1989) J. Biol. Chem. 264, 12820-12825). ...
., and Olefsky, J. M. (1988) J. Biol. Chem. 263, 8904-8911; Thies, R.S., Ulrich, A., and McClain, D. A. (1989) J. Biol. Chem. 264, 12 …
Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide.
Molina JM, Cooper GJ, Leighton B, Olefsky JM. Molina JM, et al. Among authors: olefsky jm. Diabetes. 1990 Feb;39(2):260-5. doi: 10.2337/diab.39.2.260. Diabetes. 1990. PMID: 2227135
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